Biography
Bojana Gligorijevic, PhD, graduated Chemistry at University of Belgrade with an honors thesis in analytical chemistry, isolating active compounds from endemic plants. At Georgetown University, Dr. Gligorijevic’s PhD chemistry thesis took a turn when she first saw a fluorescent microscope. She ended up developing new technologies for automated 4D imaging and analysis of malaria division and metabolic processes. During her postdoctoral training in cancer biology at Albert Einstein College of Medicine, she developed new tools for intravital imaging in mouse models and contributed to the current view of tumor cell intravasation mechanism in tumor microenvironment context.
Research Interests
- Intravital imaging
- Multiphoton Microscopy
- Machine Learning Image Classification
- Fluorescent Proteins
- Cancer Complexity
- Cell Decision-making
- Extracellular Matrix Remodeling
- Tumor Microenvironments
- Mouse Models of Metastasis
- Invadopodia
- Motility & Invasion.
Courses Taught
Number | Name | Level |
|---|---|---|
BIOE 0856 | Ethical Issues in Biomedical Science, Engineering and Technology | Undergraduate |
Selected Publications
Featured
Pourfarhangi, K.E., Hoz, E.C.D.L., Cohen, A., & Gligorijevic, B. (2018). Contact guidance is cell cycle-dependent. APL Bioengineering, 2(3). doi: 10.1063/1.5026419.
Pourfarhangi, K., Bergman, A., & Gligorijevic, B. (2018). ECM Cross-Linking Regulates Invadopodia Dynamics. Biophysical Journal, 114(6), 1455-1466. doi: 10.1016/j.bpj.2018.01.027.
Bayarmagnai, B., Perrin, L., Pourfarhangi, K.E., & Gligorijevic, B. (2018). Intravital imaging of tumor cell motility in the tumor microenvironment context. doi: 10.1007/978-1-4939-7701-7_14.
Tönisen, F., Perrin, L., Bayarmagnai, B., Dries, K.v.d., Cambi, A., & Gligorijevic, B. (2017). EP4 receptor promotes invadopodia and invasion in human breast cancer. European Journal of Cell Biology, 96(2), 218-226. doi: 10.1016/j.ejcb.2016.12.005.
Bergman, A. & Gligorijevic, B. (2015). Niche construction game cancer cells play. European Physical Journal Plus, 130(10). doi: 10.1140/epjp/i2015-15203-5.
Recent
Firestein, R., Marcinkiewicz, C., Nie, L., Chua, H., Quesada, I., Torelli, M., Sternberg, M., Gligorijevic, B., Shenderova, O., Schirhagl, R., & Feuerstein, G. (2021). Pharmacodynamic studies of fluorescent diamond carriers of doxorubicin in liver cancer cells and colorectal cancer organoids. Nanotechnology, Science and Applications, 14, 139-159. doi: 10.2147/NSA.S321725.
Perrin, L., Tucker, T., & Gligorijevic, B. (2021). Time-resolved fluorescence imaging and analysis of cancer cell invasion in the 3d spheroid model. Journal of Visualized Experiments, 2021(167). doi: 10.3791/61902.
Gligorijevic, B. (2020). Real-time, high-resolution microscopy of invasive cancer cells in the tumor microenvironment context. Journal of Biomolecular Techniques : JBT, 31, S40.
Perrin, L., Bayarmagnai, B., & Gligorijevic, B. (2020). Frontiers in intravital multiphoton microscopy of cancer. Cancer Reports, 3(1). doi: 10.1002/cnr2.1192.
Pourfarhangi, K.E., Bergman, A., & Gligorijevic, B. (2019). Invadopodia Dynamics is Regulated by ECM Cross-Linking. BIOPHYSICAL JOURNAL, 116(3), 414A-414A. Retrieved from http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000460779802082&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=abcd71df5a6dac31fd219478b0a9c638.
Pourfarhangi, K. & Gligorijevic, B. (2019). Machine Learning Classification of Cancer Cells Migration in 3D Multi-cue Microenvironments 1. 2018 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2018 - Proceedings. doi: 10.1109/SPMB.2018.8615608.
Bayarmagnai, B., Perrin, L., Pourfarhangi, K., Graña, X., Tüzel, E., & Gligorijevic, B. (2019). Invadopodia-mediated ECM degradation is enhanced in the G1 phase of the cell cycle. Journal of Cell Science, 132(20). doi: 10.1242/jcs.227116.
Bayarmagnai, B., Perrin, L., Pourfarhangi, K.E., & Gligorijevic, B. (2018). lnvadopodia are enriched in the G1 phase of the cell cycle. MOLECULAR BIOLOGY OF THE CELL, 29(26), 227-227. Retrieved from http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000505772700292&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=abcd71df5a6dac31fd219478b0a9c638.
Pourfarhangi, K.E., Bayarmagnai, B., Perrin, L., & Gligorijevic, B. (2018). Integrin beta 1 is the master regulator of the Invadopodia state in breast carcinoma cells. MOLECULAR BIOLOGY OF THE CELL, 29(26). Retrieved from http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000505772703175&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=abcd71df5a6dac31fd219478b0a9c638.
Perrin, L. & Gligorijevic, B. (2018). EMT is decoupled from invadopodia and metastasis. MOLECULAR BIOLOGY OF THE CELL, 29(26), 225-226. Retrieved from http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000505772700290&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=abcd71df5a6dac31fd219478b0a9c638.
Pourfarhangi, K.E., Hoz, E.C.D.L., Cohen, A., & Gligorijevic, B. (2018). Contact guidance is cell cycle-dependent. MOLECULAR BIOLOGY OF THE CELL, 29(26). Retrieved from http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000505772701175&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=abcd71df5a6dac31fd219478b0a9c638.
Soboloff, J., Gligorijevic, B., & Zaidi, M. (2018). STIM1 (c)AMPs up melanogenesis. The EMBO Journal, 37(5). doi: 10.15252/embj.201899047.
Bergman, A. & Gligorijevic, B. (2018). Real-time imaging of invadopodia in tumor microenvironment context. Optics InfoBase Conference Papers, Part F89-MICROSCOPY 2018. doi: 10.1364/MICROSCOPY.2018.MF3A.3.
Pourfarhangi, K., Bayarmagnai, B., Hoz, E.d.l., Cohen, A., & Gligorijevic, B. (2018). A methodology to investigate the relationship between cancer cells cell-cycle phase and their migratory behaviors. Optics InfoBase Conference Papers, Part F91-TRANSLATIONAL 2018. doi: 10.1364/TRANSLATIONAL.2018.JTu3A.13.
Pourfarhangi, K., Bergman, A., & Gligorijevic, B. (2017). Integrating live-cell fluorescent microscopy and signal processing to discover the relationship of invadopodia digging cycles with extracellular matrix crosslinking ratio. 2016 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2016 - Proceedings. doi: 10.1109/SPMB.2016.7846865.
Perrin, L. & Gligorijevic, B. (2022). Role of Laminin Matrikines in Phenotypic Switching of Motile Cancer Cells. MOLECULAR BIOLOGY OF THE CELL, 28. Retrieved from http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000426664300282&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=abcd71df5a6dac31fd219478b0a9c638.
Bayarmagnai, B., Perrin, L., Pourfarhangi, K.E., & Gligorijevic, B. (2022). Invadopodia are limited to the G1 phase of cell cycle. MOLECULAR BIOLOGY OF THE CELL, 28. Retrieved from http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000426660800217&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=abcd71df5a6dac31fd219478b0a9c638.