Biography
Dr. Gao is a key investigator for several of Dr. Koch's federally funded research awards. He is primarily responsible for mouse, rat, and rabbit physiology and gene delivery to rats, rabbits, and pigs. He is responsible and extensively trained in cardiac physiology and cardiac surgery, specifically in rat and mouse models such as myocardial infarction.
Google Scholar: Erhe Gao
Research Interests
- The role of G protein-coupled receptor kinase 2 and 5 (GRK2 and 5) in the heart including the impacts on I/R induced apoptosis, post-MI heart remodeling and cardiac regeneration.
- The role of EPO in the regulation of cardiac protection in model of myocardial ischemia and reperfusion injury.
- The role of G protein q (Gαq) on post-MI heart remodeling
- Animal model of human disease in Translational Medicine. eg. Method of myocardial infarction in mouse, method of myocardial ischemia-reperfusion injury in mouse.
- By using extremely efficient methods of myocardial infarction (MI), myocardial ischemia/reperfusion injury I/R), transvers aortic constriction (TAC), and unique approach of cardiac gene and cell delivery and powerful physiologic and histologic monitoring tools, my laboratory also interests in compounds screening, gene, and cell therapies.
Selected Publications
Recent
Zhong, C., Min, K., Zhao, Z., Zhang, C., Gao, E., Huang, Y., Zhang, X., Baldini, M., Roy, R., Yang, X., Koch, W.J., Bennett, A.M., & Yu, J. (2021). MAP Kinase Phosphatase-5 Deficiency Protects Against Pressure Overload-Induced Cardiac Fibrosis. Frontiers in Immunology, 12, 790511. doi: 10.3389/fimmu.2021.790511.
Lu, L., Ma, J., Liu, Y., Shao, Y., Xiong, X., Duan, W., Gao, E., Yang, Q., Chen, S., Yang, J., Ren, J., Zheng, Q., & Liu, J. (2021). FSTL1-USP10-Notch1 Signaling Axis Protects Against Cardiac Dysfunction Through Inhibition of Myocardial Fibrosis in Diabetic Mice. Frontiers in Cell and Developmental Biology, 9, 757068. doi: 10.3389/fcell.2021.757068.
Liu, Y., Yang, H., Song, L., Li, N., Han, Q., Tian, C., Gao, E., Du, J., Xia, Y., & Li, H. (2021). Correction to: AGGF1 protects from myocardial ischemia/reperfusion injury by regulating myocardial apoptosis and angiogenesis (Apoptosis, (2014), 19, 8, (1254-1268), 10.1007/s10495-014-1001-4). Apoptosis, 26(11-12), 657-659. doi: 10.1007/s10495-021-01695-9.
Peng, H., Shindo, K., Donahue, R., Gao, E., Ahern, B., Levitan, B., Tripathi, H., Powell, D., Noor, A., Elmore, G., Satin, J., Seifert, A., & Abdel-Latif, A. (2021). Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction. Npj Regenerative Medicine, 6(1). doi: 10.1038/s41536-021-00186-4.
Al‑Darraji, A., Donahue, R., Tripathi, H., Peng, H., Levitan, B., Chelvarajan, L., Haydar, D., Gao, E., Henson, D., Gensel, J., Feola, D., Venditto, V., & Abdel‑Latif, A. (2021). Author Correction: Liposomal delivery of azithromycin enhances its immunotherapeutic efficacy and reduces toxicity in myocardial infarction (Scientific Reports, (2020), 10, 1, (16596), 10.1038/s41598-020-73593-0). Scientific Reports, 11(1). doi: 10.1038/s41598-021-85720-6.
Gan, L., Liu, D., Xie, D., Lau, W.B., Liu, J., Christopher, T.A., Lopez, B., Liu, L., Hu, H., Yao, P., He, Y., Gao, E., Koch, W.J., Zhao, J., Ma, X., Cao, Y., & Wang, Y. (2021). Ischemic Heart-Derived Small Extracellular Vesicles Impair Adipocyte Function. Circulation Research. doi: 10.1161/circresaha.121.320157.
Xu, J., Cui, J., Lin, Q., Chen, X., Zhang, J., Gao, E., Wei, B., & Zhao, W. (2021). Protection of the enhanced Nrf2 deacetylation and its downstream transcriptional activity by SIRT1 in myocardial ischemia/reperfusion injury. International Journal of Cardiology, 342, 82-93. doi: 10.1016/j.ijcard.2021.08.007.
Lin, C., Guo, Y., Xia, Y., Li, C., Xu, X., Qi, T., Zhang, F., Fan, M., Hu, G., Zhao, H., Zhao, H., Liu, R., Gao, E., Yan, W., & Tao, L. (2021). FNDC5/Irisin attenuates diabetic cardiomyopathy in a type 2 diabetes mouse model by activation of integrin αV/β5-AKT signaling and reduction of oxidative/nitrosative stress. Journal of Molecular and Cellular Cardiology, 160, 27-41. doi: 10.1016/j.yjmcc.2021.06.013.
Ferrero, K., Pfleger, J.M., Chuprun, K., Barr, E., Gao, E., & Koch, W.J. (2021). Abstract MP247: Mitochondrial Complex V Is Regulated By GRK2 In The Heart. Circulation Research, 129(Suppl_1). doi: 10.1161/res.129.suppl_1.mp247.
Zhu, H., Zhang, L., Zhai, M., Xia, L., Cao, Y., Xu, L., Li, K., Jiang, L., Shi, H., Li, X., Zhou, Y., Ding, W., Wang, D., Gao, E., Liu, J., Yu, S., & Duan, W. (2021). GDF11 Alleviates Pathological Myocardial Remodeling in Diabetic Cardiomyopathy Through SIRT1-Dependent Regulation of Oxidative Stress and Apoptosis. Frontiers in Cell and Developmental Biology, 9. doi: 10.3389/fcell.2021.686848.
Wang, N., Ma, J., Ma, Y., Lu, L., Ma, C., Qin, P., Gao, E., Zuo, M., Yang, J., & Yang, L. (2021). Electroacupuncture Pretreatment Mitigates Myocardial Ischemia/Reperfusion Injury via XBP1/GRP78/Akt Pathway. Frontiers in Cardiovascular Medicine, 8, 629547. doi: 10.3389/fcvm.2021.629547.
Okyere, A., McEachern, E., Strong, J., Teplitsky, D., Issiako, F., Carter, R., Gao, E., & Tilley, D. (2021). Myeloid Cell‐Specific Epidermal Growth Factor Receptor (EGFR) Regulates the Immune Response in the Infarcted Heart. The FASEB Journal, 35(S1). doi: 10.1096/fasebj.2021.35.s1.05249.
Schumacher, S., Bledzka, K., Manaserh, I., Grondolsky, J., Roy, R., Gao, E., & Koch, W. (2021). Enhanced insulin‐responsive AS160 elicits cardioprotection during metabolic stress. The FASEB Journal, 35(S1). doi: 10.1096/fasebj.2021.35.s1.00202.
Liu, D., Gu, G., Gan, L., Yan, W., Zhang, Z., Yao, P., Zhu, D., Lau, W., Xie, D., Wu, S., Meng, Z., Tsukuda, J., Christopher, T., Lopez, B., Zhao, J., Gao, E., Koch, W., Ma, X., & Wang, Y. (2021). Identification of a CTRP9 C-Terminal polypeptide capable of enhancing bone-derived mesenchymal stem cell cardioprotection through promoting angiogenic exosome production. Redox Biology, 41. doi: 10.1016/j.redox.2021.101929.
Bledzka, K., Manaserh, I., Grondolsky, J., Pfleger, J., Roy, R., Gao, E., Chuprun, J., Koch, W., & Schumacher, S. (2021). A peptide of the amino-terminus of GRK2 induces hypertrophy and yet elicits cardioprotection after pressure overload. Journal of Molecular and Cellular Cardiology, 154, 137-153. doi: 10.1016/j.yjmcc.2021.01.004.
Guo, S., Okyere, A.D., McEachern, E., Strong, J.L., Carter, R.L., Patwa, V.C., Thomas, T.P., Landy, M., Song, J., Lucchese, A.M., Martin, T.G., Gao, E., Rajan, S., Kirk, J.A., Koch, W.J., Cheung, J.Y., & Tilley, D.G. (2021). Epidermal growth factor receptor-dependent maintenance of cardiac contractility. Cardiovascular Research. doi: 10.1093/cvr/cvab149.
Kwon, J., Schumacher, S., Gao, E., Chuprun, J., Ibetti, J., Roy, R., Khan, M., Kishore, R., & Koch, W. (2021). Characterization of βaRKct engineered cellular extracellular vesicles and model specific cardioprotection. American Journal of Physiology - Heart and Circulatory Physiology, 320(4), H1276-H1289. doi: 10.1152/AJPHEART.00571.2020.
Mao, C., Li, D., Zhou, E., Gao, E., Zhang, T., Sun, S., Gao, L., Fan, Y., & Wang, C. (2021). Extracellular vesicles from anoxia preconditioned mesenchymal stem cells alleviate myocardial ischemia/reperfusion injury. Aging, 13(4), 6156-6170. doi: 10.18632/aging.202611.
Peng, H., Chelvarajan, L., Donahue, R., Gottipati, A., Cahall, C., Davis, K., Tripathi, H., Al-Darraji, A., Elsawalhy, E., Dobrozsi, N., Srinivasan, A., Levitan, B., Kong, R., Gao, E., Abdel-Latif, A., & Berron, B. (2021). Polymer Cell Surface Coating Enhances Mesenchymal Stem Cell Retention and Cardiac Protection. ACS Applied Bio Materials, 4(2), 1655-1667. doi: 10.1021/acsabm.0c01473.
Lucia, C.d., Grisanti, L.A., Borghetti, G., Piedepalumbo, M., Ibetti, J., Lucchese, A.M., Barr, E.W., Roy, R., Okyere, A.D., Murphy, H.C., Gao, E., Rengo, G., Houser, S.R., Tilley, D.G., & Koch, W.J. (2021). GRK5 contributes to impaired cardiac function and immune cell recruitment in post-ischemic heart failure. Cardiovascular Research, cvab044-. doi: 10.1093/cvr/cvab044.
Eguchi, A., Coleman, R., Gresham, K., Gao, E., Ibetti, J., Chuprun, J., & Koch, W. (2021). GRK5 is a regulator of fibroblast activation and cardiac fibrosis. Proceedings of the National Academy of Sciences of the United States of America, 118(5). doi: 10.1073/pnas.2012854118.
Hoffman, M., Palioura, D., Kyriazis, I., Cimini, M., Badolia, R., Rajan, S., Gao, E., Nikolaidis, N., Schulze, P., Goldberg, I., Kishore, R., Yang, V., Bannister, T., Bialkowska, A., Selzman, C., Drakos, S., & Drosatos, K. (2021). Cardiomyocyte Krüppel-Like Factor 5 Promotes de Novo Ceramide Biosynthesis and Contributes to Eccentric Remodeling in Ischemic Cardiomyopathy. Circulation, 1139-1156. doi: 10.1161/CIRCULATIONAHA.120.047420.
Lucia, C.d., Piedepalumbo, M., Wang, L., Neto, F.C., Raftery, D., Gao, E., Praticò, D., Promislow, D., & Koch, W. (2021). Effects of myocardial ischemia/reperfusion injury on plasma metabolomic profile during aging. Aging Cell, 20(1). doi: 10.1111/acel.13284.
Huo, J., Jiao, L., An, Q., Chen, X., Qi, Y., Wei, B., Zheng, Y., Shi, X., Gao, E., Liu, H., Chen, D., Wang, C., & Zhao, W. (2021). Myofibroblast Deficiency of LSD1 Alleviates TAC-Induced Heart Failure. Circulation Research, 400-413. doi: 10.1161/CIRCRESAHA.120.318149.
Brun, M., Song, K., Kang, B., Lueck, C., Chen, W., Thatcher, K., Gao, E., Koch, W., Lincoln, J., Rajan, S., & Suh, J. (2020). Constructing and evaluating caspase-activatable adeno-associated virus vector for gene delivery to the injured heart. Journal of Controlled Release, 328, 834-845. doi: 10.1016/j.jconrel.2020.10.058.
Tripathi, H., Al-Darraji, A., Abo-Aly, M., Peng, H., Shokri, E., Chelvarajan, L., Donahue, R.R., Levitan, B., Gao, E., Hernandez, G., Morris, A., Smyth, S., & Abdel-Latif, A. (2020). Autotaxin inhibition reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction. Journal of Molecular and Cellular Cardiology, 149, 95-114. doi: 10.1016/j.yjmcc.2020.09.011.
Al-Darraji, A., Donahue, R., Tripathi, H., Peng, H., Levitan, B., Chelvarajan, L., Haydar, D., Gao, E., Henson, D., Gensel, J., Feola, D., Venditto, V., & Abdel-Latif, A. (2020). Liposomal delivery of azithromycin enhances its immunotherapeutic efficacy and reduces toxicity in myocardial infarction. Scientific Reports, 10(1). doi: 10.1038/s41598-020-73593-0.
Garikipati, V., Verma, S., Cheng, Z., Liang, D., Truongcao, M., Cimini, M., Yue, Y., Huang, G., Wang, C., Benedict, C., Tang, Y., Mallaredy, V., Ibetti, J., Grisanti, L., Schumacher, S., Gao, E., Rajan, S., Wilusz, J., Goukassian, D., Houser, S., Koch, W., & Kishore, R. (2020). Author Correction: Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis (Nature Communications, (2019), 10, 1, (4317), 10.1038/s41467-019-11777-7). Nature Communications, 11(1). doi: 10.1038/s41467-020-15382-x.
Xie, D., Zhao, J., Guo, R., Jiao, L., Zhang, Y., Lau, W., Lopez, B., Christopher, T., Gao, E., Cao, J., Ma, X., & Wang, Y. (2020). Sevoflurane Pre-conditioning Ameliorates Diabetic Myocardial Ischemia/Reperfusion Injury Via Differential Regulation of p38 and ERK. Scientific Reports, 10(1). doi: 10.1038/s41598-019-56897-8.
Hoffman, M.K., Kyriazis, I., Palioura, D., Cimini, M., Rajan, S., Gao, E., Nikolaidis, N., Schulze, C., Goldberg, I.J., Kishore, R., Yang, V.W., Bannister, T., Bialkowska, A., Selzman, C., Drakos, S.G., & Drosatos, K. (2020). Abstract 17036: Cardiomyocyte Krüppel-Like Factor 5 Regulates Ceramide Biosynthesis and Promotes Systolic Dysfunction in Ischemic Heart Failure. Circulation, 142(Suppl_3). doi: 10.1161/circ.142.suppl_3.17036.
Tripathi, H., Shindo, K., Donahue, R., Gao, E., Morris, A.J., Smyth, S.S., & Abdel-latif, A. (2020). Abstract 16007: Myeloid-specific Deletion in Lipid Phosphate Phosphatase3 (plpp3) Increases Cardiac Inflammation. Circulation, 142(Suppl_3). doi: 10.1161/circ.142.suppl_3.16007.
Xu, C., Kong, L., Ding, P., Liu, Y., Fan, Z., Gao, E., Yang, J., & Yang, L. (2020). Melatonin ameliorates pressure overload-induced cardiac hypertrophy by attenuating Atg5-dependent autophagy and activating the Akt/mTOR pathway. Biochimica Et Biophysica Acta - Molecular Basis of Disease, 1866(10). doi: 10.1016/j.bbadis.2020.165848.
Lu, L., Ma, J., Tang, J., Liu, Y., Zheng, Q., Chen, S., Gao, E., Ren, J., Yang, L., & Yang, J. (2020). Irisin attenuates myocardial ischemia/reperfusion‐induced cardiac dysfunction by regulating ER‐mitochondria interaction through a mitochondrial ubiquitin ligase‐dependent mechanism. Clinical and Translational Medicine, 10(5), e166. doi: 10.1002/ctm2.166.
Mutlu, G.K., Ferrero, K., Roy, R., Lucchese, A.M., Gao, E., & Koch, W.J. (2020). Abstract MP122: Effects of Cardiac Beta3-Adrenoceptors on the Inhibition of G Protein-coupled Receptor Kinase 2 via S-nitrosylation. Circulation Research, 127(Suppl_1). doi: 10.1161/res.127.suppl_1.mp122.
Kwon, J.S., Gao, E., Roy, R., Ibetti, j., Chuprun, J.K., & Koch, W.J. (2020). Abstract 475: Beta-adrenoceptor Stimulation Uniquely Regulates Exosome Micro-rna Content Secreted From Cardiomyocytes in vitro and Those Found in vivo Circulating in Blood. Circulation Research, 127(Suppl_1). doi: 10.1161/res.127.suppl_1.475.
Roy, R., Shanmughapriya, S., Zhang, X., Song, J., Tomar, D., Schumacher, S.M., Gao, E., Wang, H., Cheung, J.Y., Koch, W.J., & Rajan, S. (2020). Mcur1 is a Potential Target to Modulate Cardiac Contractility and Alleviate Cardiac Function During Heart Failure. CIRCULATION RESEARCH, 127. 10.1161/res.127.suppl_1.381
Wang, T., Sun, C., Hu, L., Gao, E., Li, C., Wang, H., & Sun, D. (2020). Sirt6 stabilizes atherosclerosis plaques by promoting macrophage autophagy and reducing contact with endothelial cells. Biochemistry and Cell Biology, 98(2), 120-129. doi: 10.1139/bcb-2019-0057.
Lieu, M., Traynha, C., Lucia, C.D., Pfleger, J., Piedepalumbo, M., Roy, R., Petovic, J., Landesberg, G., Forreste, S., Hoffman, M., Grisant, L., Yuan, A., Gao, E., Drosatos, K., Eguchi, S., Scalia, R., Tille, D., & Koc, W. (2020). Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging. American Journal of Physiology - Heart and Circulatory Physiology, 318(5), H1162-H1175. doi: 10.1152/ajpheart.00094.2020.
Wang, Y., Zhang, H., Wang, Z., Wei, Y., Wang, M., Liu, M., Wang, X., Jiang, Y., Shi, G., Zhao, D., Yang, Z., Ren, Z., Li, J., Zhang, Z., Wang, Z., Zhang, B., Zong, B., Lou, X., Liu, C., Wang, Z., Zhang, H., Tao, N., Li, X., Zhang, X., Guo, Y., Ye, Y., Qi, Y., Li, H., Wang, M., Guo, R., Cheng, G., Li, S., Zhang, J., Liu, G., Chai, L., Lou, Q., Li, X., Cui, X., Gao, E., Dong, Z., Hu, Y., Chen, Y., & Ma, Y. (2020). Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats. Science Translational Medicine, 12(540). doi: 10.1126/scitranslmed.aaw3172.
Wang, Y., Liu, D., Zhu, D., Lau, W.B., Lopez, B., Christopher, T., Xie, D., Zhang, Z., Gao, E., Koch, W., & Ma, X. (2020). Identification of a CTRP9 Fragment Capable of Enhancing Bone Marrow Mesenchymal Stem Cell Cardioprotection via Cardioreparative Exosome Production Promotion. The FASEB Journal, 34(S1), 1-1. doi: 10.1096/fasebj.2020.34.s1.03929.
Ma, X., Li, D., Shen, J., Chen, S., Li, Y., Xie, L., Gao, E., & Zuo, L. (2020). Curative effect of Sca-1 positive stem cells from mice on myocardial infarction in mouse model and its mechanism in gene regulation. Chinese Journal of Biologicals, 33(4), 382-389.
Hoffman, M., Kyriazis, I., Lyons, W., Rajan, S., Gao, E., Khan, M., Bannister, T., Yang, V., Bialkowska, A., Selzman, C., Drakos, S., & Drosatos, K. Cardiomyocyte Kruppel-like Factor 5 Regulates Ceramide Biosynthesis and miR-30 Suppression in Ischemic Cardiomyopathy and Promotes Systolic Dysfunction. FASEB JOURNAL, 34. 10.1096/fasebj.2020.34.s1.07226
Tripathi, H., Peng, H., Donahue, R., Chelvarajan, L., Gottipati, A., Levitan, B., Al-Darraji, A., Gao, E., Abdel-Latif, A., & Berron, B. (2020). Isolation Methods for Human CD34 Subsets Using Fluorescent and Magnetic Activated Cell Sorting: an In Vivo Comparative Study. Stem Cell Reviews and Reports, 16(2), 413-423. doi: 10.1007/s12015-019-09939-7.
Huo, J., An, Q., Chen, X., Qin, Z., Gao, E., Chen, D., Wang, C., Liu, H., & Zhao, W. Cardiac-specific inactivation of LSD1 in mice leads to myocardial hypertrophy and heart failure. JOURNAL of MOLECULAR and CELLULAR CARDIOLOGY, 140, 45-45. 10.1016/j.yjmcc.2019.11.107
Du, Y., Wang, X., Lau, W.B., Wei, Y., Liu, H., Du, J., Yin, L., Gao, E., Koch, W., Wang, Y., & Ma, X. (2020). Adiponectin improves vascular endothelial dysfunction through caveolin-1 mediated nuclear translocation and HDAC inhibition. Journal of Molecular and Cellular Cardiology, 140, 56-57. doi: 10.1016/j.yjmcc.2019.11.136.
Lu, L., Ma, J., Yang, L., Wang, X., Gao, E., & Yang, J. (2020). Melatonin ameliorates cardiomyocytes apoptosis via JNK/p53 pathway in diabetic mice post-infarction. Journal of Molecular and Cellular Cardiology, 140, 21-22. doi: 10.1016/j.yjmcc.2019.11.049.
Gao, C., Wang, R., Li, B., Guo, Y., Yin, T., Xia, Y., Zhang, F., Lian, K., Liu, Y., Wang, H., Zhang, L., Gao, E., Yan, W., & Tao, L. (2020). TXNIP/Redd1 signalling and excessive autophagy: A novel mechanism of myocardial ischaemia/reperfusion injury in mice. Cardiovascular Research, 116(3), 645-657. doi: 10.1093/cvr/cvz152.
Ponnalagu, D., Bednarczyk, P., Weist, J., Gao, E., Koch, W., Khan, M., Szewczyk, A.M., & Singh, H. (2020). Identification of Role of Mitochondrial Chloride Intracellular Channel (CLIC) Protein, CLIC4 and CLIC5 in Cardioprotection from IR Injury via Probably Modulating the Opening of MPTP Pore. Biophysical Journal, 118(3), 446a. doi: 10.1016/j.bpj.2019.11.2495.
Chen, Y., Li, C., Li, C., Chen, J., Li, Y., Xie, H., Lin, C., Fan, M., Guo, Y., Gao, E., Yan, W., & Tao, L. (2020). Tailorable Hydrogel Improves Retention and Cardioprotection of Intramyocardial Transplanted Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice. Journal of the American Heart Association, 9(2). doi: 10.1161/JAHA.119.013784.
Gan, L., Xie, D., Liu, J., Lau, W.B., Christopher, T., Lopez, B., Zhang, L., Gao, E., Koch, W., Ma, X., & Wang, Y. (2020). Small Extracellular Microvesicles Mediated Pathological Communications between Dysfunctional Adipocytes and Cardiomyocytes as a Novel Mechanism Exacerbating Ischemia/Reperfusion Injury in Diabetic Mice. Circulation, 968-983. doi: 10.1161/CIRCULATIONAHA.119.042640.
Pfleger, J., Coleman, R., Ibetti, J., Roy, R., Kyriazis, I., Gao, E., Drosatos, K., & Koch, W. (2020). Genomic binding patterns of forkhead box protein O1 reveal its unique role in cardiac hypertrophy. Circulation, 882-898. doi: 10.1161/CIRCULATIONAHA.120.046356.
Lu, L., Ma, J., Sun, M., Wang, X., Gao, E., Lu, L., Ren, J., Yang, L., Yang, J., & Moorthy, B. (2020). Melatonin Ameliorates MI-Induced Cardiac Remodeling and Apoptosis through a JNK/p53-Dependent Mechanism in Diabetes Mellitus. Oxidative Medicine and Cellular Longevity, 2020. doi: 10.1155/2020/1535201.
Yan, W., Lin, C., Guo, Y., Chen, Y., Du, Y., Lau, W., Xia, Y., Zhang, F., Su, R., Gao, E., Wang, Y., Li, C., Liu, R., Ma, X., & Tao, L. (2020). N-cadherin overexpression mobilizes the protective effects of mesenchymal stromal cells against ischemic heart injury through a β-catenin-dependent manner. Circulation Research, 857-874. doi: 10.1161/CIRCRESAHA.119.315806.
Li, D., Mao, C., Zhou, E., You, J., Gao, E., Han, Z., Fan, Y., He, Q., & Wang, C. (2020). Microrna-21 mediates a positive feedback on angiotensin ii-induced myofibroblast transformation. Journal of Inflammation Research, 13, 1007-1020. doi: 10.2147/JIR.S285714.
Li, Y., Xiong, Z., Yan, W., Gao, E., Cheng, H., Wu, G., Liu, Y., Zhang, L., Li, C., Wang, S., Fan, M., Zhao, H., Zhang, F., & Tao, L. (2020). Branched chain amino acids exacerbate myocardial ischemia/ reperfusion vulnerability via enhancing GCN2/ATF6/PPAR-α pathway-dependent fatty acid oxidation. Theranostics, 10(12), 5623-5640. doi: 10.7150/thno.44836.
Garikipati, V., Verma, S., Cheng, Z., Liang, D., Truongcao, M., Cimini, M., Yue, Y., Huang, G., Wang, C., Benedict, C., Tang, Y., Mallaredy, V., Ibetti, J., Grisanti, L., Schumacher, S., Gao, E., Rajan, S., Wilusz, J., Goukassian, D., Houser, S., Koch, W., & Kishore, R. (2019). Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis. Nature Communications, 10(1). doi: 10.1038/s41467-019-11777-7.
Gan, L., Xie, D., Liu, J., Liu, D., Zhang, L., Zhang, Z., Gao, E., LAU, W.B., Lopez, B.L., Christopher, T., Wang, Y., & Ma, X.L. (2019). Abstract 196: Cardiac Small Extracellular Microvesicles-Induced Adipogenesis Suppression Contribute to Matabolic Disorders in Heart Failure. Circulation, 140(Suppl_2). doi: 10.1161/circ.140.suppl_2.196.
Lambert, J., Luongo, T., Tomar, D., Jadiya, P., Gao, E., Zhang, X., Lucchese, A., Kolmetzky, D., Shah, N., & Elrod, J. (2019). MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload during Stress. Circulation, 140(21), 1720-1733. doi: 10.1161/CIRCULATIONAHA.118.037968.
Xiao, Y., Song, C., Lin, Q., Shi, X., Yu, W., Huang, X., Wang, H., Chen, Y., Wang, R., Geng, X., Qin, M., Hu, K., Fan, Y., Qiao, Y., Gao, E., Zhao, W., & Chang, J. (2019). Cardioprotection of (±)-sodium 5-bromo-2-(α-hydroxypentyl) benzoate (BZP) on mouse myocardium I/R injury through inhibiting 12/15-LOX-2 activity. Journal of Molecular and Cellular Cardiology, 135, 52-66. doi: 10.1016/j.yjmcc.2019.07.014.
Zhang, Z., Tan, Y., Zhu, L., Zhang, B., Feng, P., Gao, E., Xu, C., Wang, X., Yi, W., & Sun, Y. (2019). Asprosin improves the survival of mesenchymal stromal cells in myocardial infarction by inhibiting apoptosis via the activated ERK1/2-SOD2 pathway. Life Sciences, 231. doi: 10.1016/j.lfs.2019.116554.
Ponnalagu, D., Hussain, A.T., Gao, E., & Singh, H. (2019). Abstract 585: Role of Splice Variant Clic5B in Cardiac Mitochondrial Localization and Function. Circulation Research, 125(Suppl_1). doi: 10.1161/res.125.suppl_1.585.
Lambert, J.P., Luongo, T.S., Tomar, D., Jadiya, P., Gao, E., Zhang, X., Lucchese, A.M., Kolmetzky, D.W., Shah, N., & Elrod, J.W. (2019). Abstract 857: MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel During Cardiac Stress to Limit Mitochondrial Calcium Overload. Circulation Research, 125(Suppl_1). doi: 10.1161/res.125.suppl_1.857.
Lieu, M., Traynham, C.J., Petovic, J., Landesberg, G.P., Forrester, S., Gao, E., Eguchi, S., Scalia, R., & Koch, W.J. (2019). Abstract 841: Loss of S-nitrosylation of G Protein-Coupled Receptor Kinase 2 Leads to Cardiovascular Dysfunction With Aging. Circulation Research, 125(Suppl_1). doi: 10.1161/res.125.suppl_1.841.
Gan, L., Xie, D., Lau, W., Christopher, T., Lopez, B., Zhang, L., Liu, J., Gao, E., Koch, W., Wang, Y., & Ma, X. (2019). Abstract 646: Myocardial Ischemia/Reperfusion Impairs Adipocyte Endocrine Function via Exosome-Mediated Endoplasmic Reticulum Dysfunction. Circulation Research, 125(Suppl_1). doi: 10.1161/res.125.suppl_1.646.
Han, D., Wang, Y., Chen, J., Zhang, J., Yu, P., Zhang, R., Li, S., Tao, B., Wang, Y., Qiu, Y., Xu, M., Gao, E., & Cao, F. (2019). Activation of melatonin receptor 2 but not melatonin receptor 1 mediates melatonin-conferred cardioprotection against myocardial ischemia/reperfusion injury. Journal of Pineal Research, 67(1). doi: 10.1111/jpi.12571.
Zhang, Z., Zhu, L., Feng, P., Tan, Y., Zhang, B., Gao, E., Wang, X., Fan, C., Wang, X., Yi, W., & Sun, Y. (2019). C1q/tumor necrosis factor-related protein-3-engineered mesenchymal stromal cells attenuate cardiac impairment in mice with myocardial infarction. Cell Death and Disease, 10(7). doi: 10.1038/s41419-019-1760-5.
Zhang, B., Zhang, P., Tan, Y., Feng, P., Zhang, Z., Liang, H., Duan, W., Jin, Z., Wang, X., Liu, J., Gao, E., Yu, S., Yi, D., Sun, Y., & Yi, W. (2019). C1q-TNF-related protein-3 attenuates pressure overload-induced cardiac hypertrophy by suppressing the p38/CREB pathway and p38-induced ER stress. Cell Death and Disease, 10(7). doi: 10.1038/s41419-019-1749-0.
Wang, X., Lu, L., Tan, Y., Jiang, L., Zhao, M., Gao, E., Yu, S., & Liu, J. (2019). GPR 30 reduces myocardial infarct area and fibrosis in female ovariectomized mice by activating the PI3K/AKT pathway. Life Sciences, 226, 22-32. doi: 10.1016/j.lfs.2019.03.049.
Guo, S., Song, J., Carter, R., Lucchese, A.M., Gao, E., Cheung, J., & Tilley, D. (2019). Cardiomyocyte‐Specific EGFR Deletion Differentially Alters Cardiac Contractility and Remodeling. The FASEB Journal, 33(S1), 676.9-676.9. doi: 10.1096/fasebj.2019.33.1_supplement.676.9.
Wang, Y., Gan, L., Xie, D., Lau, W.B., Liu, J., Zhang, L., Gao, E., Koch, W., & Ma, X. (2019). Exosome Mediated Globular Adiponectin's Cardioprotective Role via the Adiponectin receptor‐dependent Uptake mechanism. The FASEB Journal, 33(S1), 833.21-833.21. doi: 10.1096/fasebj.2019.33.1_supplement.833.21.
Lucia, C.d., Grisanti, L.A., Borghetti, G., Ibetti, J., Lucchese, A.M., Gao, E., Rengo, G., Houser, S.R., Tilley, D., & Koch, W.J. GRK5-mediated Exacerbation of Ischemic Heart Failure Involves Cardiac Immune and Inflammatory Responses. FASEB JOURNAL, 33. Retrieved from http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000496555200461&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=abcd71df5a6dac31fd219478b0a9c638.
Magga, J., Vainio, L., Kilpiö, T., Hulmi, J., Taponen, S., Lin, R., Räsänen, M., Szabó, Z., Gao, E., Rahtu-Korpela, L., Alakoski, T., Ulvila, J., Laitinen, M., Pasternack, A., Koch, W., Alitalo, K., Kivelä, R., Ritvos, O., & Kerkelä, R. (2019). Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury. Molecular Therapy, 27(3), 600-610. doi: 10.1016/j.ymthe.2019.01.013.
Vainio, L., Szabó, Z., Lin, R., Ulvila, J., Yrjölä, R., Alakoski, T., Piuhola, J., Koch, W., Ruskoaho, H., Fouse, S., Seeley, T., Gao, E., Signore, P., Lipson, K., Magga, J., & Kerkelä, R. (2019). Connective Tissue Growth Factor Inhibition Enhances Cardiac Repair and Limits Fibrosis After Myocardial Infarction. JACC: Basic to Translational Science, 4(1), 83-94. doi: 10.1016/j.jacbts.2018.10.007.
Cheng, Z., Zhang, M., Hu, J., Lin, J., Feng, X., Wang, S., Wang, T., Gao, E., Wang, H., & Sun, D. (2019). Cardiac-specific Mst1 deficiency inhibits ROS-mediated JNK signalling to alleviate Ang II-induced cardiomyocyte apoptosis. Journal of Cellular and Molecular Medicine, 23(1), 543-555. doi: 10.1111/jcmm.13958.
He, Y., Guo, Y., Xia, Y., Guo, Y., Wang, R., Zhang, F., Guo, L., Liu, Y., Yin, T., Gao, C., Gao, E., Li, C., Wang, S., Zhang, L., Yan, W., & Tao, L. (2019). Resistin promotes cardiac homing of mesenchymal stem cells and functional recovery after myocardial ischemia-reperfusion via the ERK1/2-MMP-9 pathway. American Journal of Physiology - Heart and Circulatory Physiology, 316(1), H233-H244. doi: 10.1152/ajpheart.00457.2018.
Hu, L., Ding, M., Tang, D., Gao, E., Li, C., Wang, K., Qi, B., Qiu, J., Zhao, H., Chang, P., Fu, F., & Li, Y. (2019). Targeting mitochondrial dynamics by regulating Mfn2 for therapeutic intervention in diabetic cardiomyopathy. Theranostics, 9(13), 3687-3706. doi: 10.7150/thno.33684.
Borden, A., Kurian, J., Nickoloff, E., Yang, Y., Troupes, C., Ibetti, J., Lucchese, A., Gao, E., Mohsin, S., Koch, W., Houser, S., Kishore, R., & Khan, M. (2019). Transient introduction of miR-294 in the heart promotes cardiomyocyte cell cycle reentry after injury. Circulation Research, 125(1), 14-25. doi: 10.1161/CIRCRESAHA.118.314223.
Grisanti, L., Lucia, C.D., Thomas, T., Stark, A., Strony, J., Myers, V., Beretta, R., Yu, D., Sardu, C., Marfella, R., Gao, E., Houser, S., Koch, W., Hamad, E., & Tilley, D. (2019). Prior beta blocker treatment decreases leukocyte responsiveness to injury. JCI Insight, 4(9). doi: 10.1172/jci.insight.99485.
Li, S., Sun, X., Wu, H., Yu, P., Wang, X., Jiang, Z., Gao, E., Chen, J., Li, D., Qiu, C., Song, B., Chen, K., He, K., Yang, D., & Yang, Y. (2019). TRPA1 promotes cardiac myofibroblast transdifferentiation after myocardial infarction injury via the calcineurin-NFAT-DYRK1A signaling pathway. Oxidative Medicine and Cellular Longevity, 2019. doi: 10.1155/2019/6408352.
Wang, B., Shen, D., Tang, J., Li, J., Xiao, Y., Chen, X., Cao, C., Han, D., Gao, E., Zhao, W., Zhang, J., & Chang, J. (2019). Sodium (±)-5-bromo-2-(α-hydroxypentyl) benzoate ameliorates pressure overload-induced cardiac hypertrophy and dysfunction through inhibiting autophagy. Journal of Cellular and Molecular Medicine, 23(9), 6048-6059. doi: 10.1111/jcmm.14468.
Guo, R., Gan, L., Lau, W., Yan, Z., Xie, D., Gao, E., Christopher, T., Lopez, B., Ma, X., & Wang, Y. (2019). Withaferin a prevents myocardial ischemia/reperfusion injury by upregulating AMP-activated protein kinase-dependent B-cell lymphoma2 signaling. Circulation Journal, 83(8), 1726-1736. doi: 10.1253/circj.CJ-18-1391.
Sato, P., Chuprun, J.K., Grisanti, L., Woodall, M., Brown, B., Roy, R., Traynham, C., Ibetti, J., Lucchese, A., Yuan, A., Drosatos, K., Tilley, D., Gao, E., & Koch, W. (2018). Restricting mitochondrial GRK2 post-ischemia confers cardioprotection by reducing myocyte death and maintaining glucose oxidation. Science Signaling, 11(560). doi: 10.1126/scisignal.aau0144.
Meier, S., Gilad, A., Brandon, J., Qian, C., Gao, E., Abisambra, J., & Vandsburger, M. (2018). Non-invasive detection of adeno-associated viral gene transfer using a genetically encoded CEST-MRI reporter gene in the murine heart. Scientific Reports, 8(1). doi: 10.1038/s41598-018-22993-4.
Kinnunen, S., Tölli, M., Välimäki, M., Gao, E., Szabo, Z., Rysä, J., Ferreira, M., Ohukainen, P., Serpi, R., Correia, A., Mäkilä, E., Salonen, J., Hirvonen, J., Santos, H., & Ruskoaho, H. (2018). Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4-NKX2-5 Interaction. Scientific Reports, 8(1). doi: 10.1038/s41598-018-22830-8.
Cheng, Z., Zhang, M., Hu, J., Lin, J., Feng, X., Wang, S., Wang, T., Gao, E., Wang, H., & Sun, D. (2018). Mst1 knockout enhances cardiomyocyte autophagic flux to alleviate angiotensin II-induced cardiac injury independent of angiotensin II receptors. Journal of Molecular and Cellular Cardiology, 125, 117-128. doi: 10.1016/j.yjmcc.2018.08.028.
Pfleger, J.M., Gross, P., Johnson, J., Gao, E., Houser, S.R., & Koch, W.J. G Protein-coupled receptor kinase 2 impairs fatty acid metabolism in the failing heart through novel mechanisms. JOURNAL of MOLECULAR and CELLULAR CARDIOLOGY, 124, 100-100. 10.1016/j.yjmcc.2018.07.055
Hu, J., Wang, S., Xiong, Z., Cheng, Z., Yang, Z., Lin, J., Wang, T., Feng, X., Gao, E., Wang, H., & Sun, D. (2018). Exosomal Mst1 transfer from cardiac microvascular endothelial cells to cardiomyocytes deteriorates diabetic cardiomyopathy. Biochimica Et Biophysica Acta - Molecular Basis of Disease, 1864(11), 3639-3649. doi: 10.1016/j.bbadis.2018.08.026.
Yan, W., Xia, Y., Zhang, F., Guo, Y., Guo, Y., He, Y., Liu, Y., Wang, R., Yin, T., Gao, E., Ma, X., & Tao, L. (2018). GW29-e1697 Activation of Farnesoid X Receptor enhances the survival of engrafted adipose-derived mesenchymal stem cells in mouse post-MI heart. Journal of the American College of Cardiology, 72(16), c74. doi: 10.1016/j.jacc.2018.08.421.
Yan, W., Guo, Y., He, Y., Xia, Y., Zhang, F., Guo, Y., Liu, Y., Wang, R., Yin, T., Gao, E., & Tao, L. (2018). GW29-e1694 Resistin-pretreatment promotes homing of mesenchymal stem cells into damaged heart for functional recovery after myocardial ischemia/reperfusion via ERK1/2-MMP-9 signaling pathway. Journal of the American College of Cardiology, 72(16), c55. doi: 10.1016/j.jacc.2018.08.200.
Klyachkin, Y., Idris, A., Rodell, C., Tripathi, H., Ye, S., Nagareddy, P., Asfour, A., Gao, E., Annabathula, R., Ratajczak, M., Burdick, J., & Abdel-Latif, A. (2018). Cathelicidin Related Antimicrobial Peptide (CRAMP) Enhances Bone Marrow Cell Retention and Attenuates Cardiac Dysfunction in a Mouse Model of Myocardial Infarction. Stem Cell Reviews and Reports, 14(5), 702-714. doi: 10.1007/s12015-018-9833-x.
Pfleger, J., Gross, P., Johnson, J., Carter, R., Gao, E., Tilley, D., Houser, S., & Koch, W. (2018). G protein-coupled receptor kinase 2 contributes to impaired fatty acid metabolism in the failing heart. Journal of Molecular and Cellular Cardiology, 123, 108-117. doi: 10.1016/j.yjmcc.2018.08.025.
Zhang, J., Tian, X., Peng, C., Yan, C., Li, Y., Sun, M., Kang, J., Gao, E., & Han, Y. (2018). Transplantation of CREG modified embryonic stem cells improves cardiac function after myocardial infarction in mice. Biochemical and Biophysical Research Communications, 503(2), 482-489. doi: 10.1016/j.bbrc.2018.04.160.
Guo, S., Lambert, J., Song, J., Carter, R., Lucchese, A.M., Gao, E., Cheung, J., Elrod, J., & Tilley, D. (2018). Abstract 423: Cardiomyocyte-Specific Epidermal Growth Factor Receptor Deletion Differentially Alters Cardiac Contractility and Remodeling During Physiologic versus Pathologic Development. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.423.
Lambert, J.P., Luongo, T.S., Jadiya, P., Gao, E., Lucchesee, A.M., Zhang, X., Kolmetzky, D.W., Shah, N., & Elrod, J.W. (2018). Abstract 539: MCUB Regulates the Macromolecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Ischemic Cardiac Injury. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.539.
Grisanti, L.A., Thomas, T.P., Lucia, C.d., Carter, R.L., Gao, E., Koch, W.J., Benovic, J.L., & Tilley, D.G. (2018). Abstract 580: A β-arrestin-Biased β2-Adrenergic Receptor-Specific Pepducin Confers Cardioprotection. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.580.
Garikipati, V.N., Verma, S.K., Cheng, Z., Liang, D., Truongcao, M.M., Cimini, M., Wang, C., Benedict, C., Ibetti, J., Grisanti, L., Schumacher, S.M., Gao, E., Rajan, S., Wilusz, J.E., Goukassian, D., Houser, S., Koch, W.J., & Kishore, R. (2018). Abstract 288: Circular RNA CircFNDC3b Modulates Cardiac Repair After Myocardial Infarction via FUS-1/VEGF-A Axis. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.288.
Wang, Y., Gan, L., Xie, D., Zhao, D., Gao, E., Koch, W.J., & Ma, X. (2018). Abstract 557: Exosome Biogenesis/Uptake Mediates Cardioprotection by Globular Adiponectin but Not High Molecular Weight Adiponectin. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.557.
Lieu, M., Chuprun, K., Gao, E., & Koch, W.J. (2018). Abstract 318: MicroRNA Regulation of G Protein-Coupled Receptor Kinase 2 After Cardiac Injury. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.318.
Ponnalagu, D., Patel, N.J., Gao, E., Koch, W.J., Kohut, A.R., & Singh, H. (2018). Abstract 292: Mitochondrial CLIC4 and CLIC5B Mediate Cardio-protection From Ischemia/reperfusion Injury. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.292.
Gan, L., Xie, D., Zhao, D., Gao, E., Koch, W.J., Wang, Y., & Ma, X. (2018). Abstract 220: Adipocyte-Derived Exosome-Containing miRNAs Exacerbated Cardiac Ischemia/Reperfusion Injury in Diabetic Mice. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.220.
Pfleger, J.M., Gross, P., Johnson, J., Gao, E., Houser, S.R., & Koch, W.J. (2018). G Protein-coupled Receptor Kinase 2 Impairs Fatty Acid Metabolism in the Failing Heart Through Novel Mechanisms. CIRCULATION RESEARCH, 123. 10.1161/res.123.suppl_1.109
Xia, Y., Zhang, F., Zhao, S., Li, Y., Chen, X., Gao, E., Xu, X., Xiong, Z., Zhang, X., Zhang, J., Zhao, H., Wang, W., Wang, H., Guo, Y., Liu, Y., Li, C., Wang, S., Zhang, L., Yan, W., & Tao, L. (2018). Adiponectin determines farnesoid X receptor agonism-mediated cardioprotection against post-infarction remodelling and dysfunction. Cardiovascular Research, 114(10), 1335-1349. doi: 10.1093/cvr/cvy093.
Al-Darraji, A., Haydar, D., Chelvarajan, L., Tripathi, H., Levitan, B., Gao, E., Venditto, V., Gensel, J., Feola, D., & Abdel-Latif, A. (2018). Azithromycin therapy reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction: Potential therapeutic targets in ischemic heart disease. PLoS ONE, 13(7). doi: 10.1371/journal.pone.0200474.
Zhao, D., Feng, P., Sun, Y., Qin, Z., Zhang, Z., Tan, Y., Gao, E., Lau, W., Ma, X., Yang, J., Yu, S., Xu, X., Yi, D., & Yi, W. (2018). Cardiac-derived CTRP9 protects against myocardial ischemia/reperfusion injury via calreticulin-dependent inhibition of apoptosis article. Cell Death and Disease, 9(7). doi: 10.1038/s41419-018-0726-3.
Ponnalagu, D., Patel, N.J., Chaudhury, A., Gao, E., Koch, W.J., Kohut, A.R., & Singh, H. (2018). CLIC4 and CLIC5, Mitochondrial Chloride Channel Proteins Mediate Cardioprotection Against Ischemia Reperfusion Injury. Biophysical Journal, 114(3), 657a. doi: 10.1016/j.bpj.2017.11.3551.
Manning, J., Chelvarajan, L., Levitan, B., Withers, C., Nagareddy, P., Haggerty, C., Fornwalt, B., Gao, E., Tripathi, H., Abdel-Latif, A., Andres, D., & Satin, J. (2018). Rad GTPase Deletion Attenuates Post-Ischemic Cardiac Dysfunction and Remodeling. JACC: Basic to Translational Science, 3(1), 83-96. doi: 10.1016/j.jacbts.2017.09.004.
Grisanti, L., Thomas, T., Carter, R., Lucia, C.d., Gao, E., Koch, W., Benovic, J., & Tilley, D. (2018). Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling. Theranostics, 8(17), 4664-4678. doi: 10.7150/thno.26619.
Li, S., Wu, H., Han, D., Zhang, M., Li, N., Yu, W., Sun, D., Sun, Z., Ma, S., Gao, E., Li, C., Shen, M., & Cao, F. (2018). ZP2495 Protects against Myocardial Ischemia/Reperfusion Injury in Diabetic Mice through Improvement of Cardiac Metabolism and Mitochondrial Function: The Possible Involvement of AMPK-FoxO3a Signal Pathway. Oxidative Medicine and Cellular Longevity, 2018. doi: 10.1155/2018/6451902.
Yan, W., Guo, Y., Tao, L., Lau, W., Gan, L., Yan, Z., Guo, R., Gao, E., Wong, G., Koch, W., Wang, Y., & Ma, X. (2017). C1q/Tumor Necrosis Factor-Related Protein-9 Regulates the Fate of Implanted Mesenchymal Stem Cells and Mobilizes Their Protective Effects Against Ischemic Heart Injury via Multiple Novel Signaling Pathways. Circulation, 136(22), 2162-2177. doi: 10.1161/CIRCULATIONAHA.117.029557.
Wang, Y., Liang, B., Lau, W., Du, Y., Guo, R., Yan, Z., Gan, L., Yan, W., Zhao, J., Gao, E., Koch, W., & Ma, X. (2017). Restoring diabetes-induced autophagic flux arrest in ischemic/reperfused heart by ADIPOR (adiponectin receptor) activation involves both AMPK-dependent and AMPK-independent signaling. Autophagy, 13(11), 1855-1869. doi: 10.1080/15548627.2017.1358848.
Sato, P., Chuprun, J.K., Grisanti, L., Woodall, M., Traynham, C., Lucchese, A.M., Yuan, A., Ibetti, J., Tilley, D., Gao, E., & Koch, W. (2017). GRK2-S670A Mice reveal cardioprotection post ischemia-reperfusion. Journal of Molecular and Cellular Cardiology, 112, 152-153. doi: 10.1016/j.yjmcc.2017.07.067.
Hu, J., Zhang, L., Yang, Y., Gao, E., & Sun, D. (2017). Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 70(16), C23-C23. 10.1016/j.jacc.2017.07.079
Zhai, M., Li, B., Duan, W., Jing, L., Zhang, B., Zhang, M., Yu, L., Liu, Z., Yu, B., Ren, K., Gao, E., Yang, Y., Liang, H., Jin, Z., & Yu, S. (2017). Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis. Journal of Pineal Research, 63(2). doi: 10.1111/jpi.12419.
Zhang, M., Lin, J., Wang, S., Cheng, Z., Hu, J., Wang, T., Man, W., Yin, T., Guo, W., Gao, E., Reiter, R., Wang, H., & Sun, D. (2017). Melatonin protects against diabetic cardiomyopathy through Mst1/Sirt3 signaling. Journal of Pineal Research, 63(2). doi: 10.1111/jpi.12418.
Hu, J., Zhang, L., Zhao, Z., Zhang, M., Lin, J., Wang, J., Yu, W., Man, W., Li, C., Zhang, R., Gao, E., Wang, H., & Sun, D. (2017). OSM mitigates post-infarction cardiac remodeling and dysfunction by up-regulating autophagy through Mst1 suppression. Biochimica Et Biophysica Acta - Molecular Basis of Disease, 1863(8), 1951-1961. doi: 10.1016/j.bbadis.2016.11.004.
Song, H., Yan, C., Tian, X., Zhu, N., Li, Y., Liu, D., Liu, Y., Liu, M., Peng, C., Zhang, Q., Gao, E., & Han, Y. (2017). CREG protects from myocardial ischemia/reperfusion injury by regulating myocardial autophagy and apoptosis. Biochimica Et Biophysica Acta - Molecular Basis of Disease, 1863(8), 1893-1903. doi: 10.1016/j.bbadis.2016.11.015.
Lambert, J.P., Luongo, T.S., Jadiya, P., Gao, E., Zhang, X., Lucchesee, A.M., & Elrod, J.W. (2017). Abstract 432: MCUB Regulates Mitochondrial Calcium Uniporter Channel Gating and Modulates Bioenergetics and Cell Death. Circulation Research, 121(suppl_1). doi: 10.1161/res.121.suppl_1.432.
Grisanti, L.A., Lucia, C.d., Gao, E., Koch, W.J., Benovic, J.L., & Tilley, D.G. (2017). Abstract 299: Cardioprotection from Ischemia/Reperfusion Injury by β-Arrestin-Biased β2-Adrenergic Receptor Activation. Circulation Research, 121(suppl_1). doi: 10.1161/res.121.suppl_1.299.
Wang, Y., Lau, W., Lopez, B., Christopher, T., Gao, E., Koch, W., & Ma, X.X. (2017). Abstract 362: Restoring Diabetes-induced Autophagic Flux Arrestment in Ischemic/Reperfused Heart by Adiponectin Receptor Activation Involves Both AMPK-Dependent and AMPK-Independent Signaling. Circulation Research, 121(suppl_1). doi: 10.1161/res.121.suppl_1.362.
Yan, W., Lau, W., Christopher, T., Lopez, B., Gao, E., Koch, W., Wang, Y., & Ma, X.X. (2017). Abstract 308: CTRP9 Regulates the Fate of Implanted Mesenchymal Stem Cells and Mobilizes Their Protective Effects Against Ischemic Heart Injury via Multiple Novel Signaling Pathways. Circulation Research, 121(suppl_1). doi: 10.1161/res.121.suppl_1.308.
Xue, Q., Pei, H., Liu, Q., Zhao, M., Sun, J., Gao, E., Ma, X., & Tao, L. (2017). MICU1 protects against myocardial ischemia/reperfusion injury and its control by the importer receptor Tom70. Cell Death & Disease, 8(7), e2923. doi: 10.1038/cddis.2017.280.
Garikipati, V., Verma, S., Jolardarashi, D., Cheng, Z., Ibetti, J., Cimini, M., Tang, Y., Khan, M., Yue, Y., Benedict, C., Nickoloff, E., Truongcao, M., Gao, E., Krishnamurthy, P., Goukassian, D., Koch, W., & Kishore, R. (2017). Therapeutic inhibition of miR-375 attenuates post-myocardial infarction inflammatory response and left ventricular dysfunction via PDK-1-AKT signalling axis. Cardiovascular Research, 113(8), 938-949. doi: 10.1093/cvr/cvx052.
Zhao, S., Xia, Y., Zhang, F., Xiong, Z., Li, Y., Yan, W., Chen, X., Wang, W., Wang, H., Gao, E., Lee, Y., Li, C., Wang, S., Zhang, L., & Tao, L. (2017). Nucleostemin dysregulation contributes to ischemic vulnerability of diabetic hearts: Role of ribosomal biogenesis. Journal of Molecular and Cellular Cardiology, 108, 106-113. doi: 10.1016/j.yjmcc.2017.05.010.
Schlegel, P., Reinkober, J., Meinhardt, E., Tscheschner, H., Gao, E., Schumacher, S., Yuan, A., Backs, J., Most, P., Wieland, T., Koch, W., Katus, H., & Raake, P. (2017). G protein-coupled receptor kinase 2 promotes cardiac hypertrophy. PLoS ONE, 12(7). doi: 10.1371/journal.pone.0182110.
Luongo, T., Lambert, J., Gross, P., Nwokedi, M., Lombardi, A., Shanmughapriya, S., Carpenter, A., Kolmetzky, D., Gao, E., Berlo, J.V., Tsai, E., Molkentin, J., Chen, X., Madesh, M., Houser, S., & Elrod, J. (2017). The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability. Nature, 545(7652), 93-97. doi: 10.1038/nature22082.
Eisner, V., Cupo, R., Gao, E., Csordás, G., Slovinsky, W., Paillard, M., Cheng, L., Ibetti, J., Chen, S., Chuprun, J., Hoek, J., Koch, W., & Hajnóczky, G. (2017). Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity. Proceedings of the National Academy of Sciences of the United States of America, 114(5), E859-E868. doi: 10.1073/pnas.1617288114.
Pei, H., Hou, J., Wei, F., Xue, Q., Zhang, F., Peng, C., Yang, Y., Tian, Y., Feng, J., Du, J., He, L., Li, X., Gao, E., Li, D., & Yang, Y. (2017). Melatonin attenuates postmyocardial infarction injury via increasing Tom70 expression. Journal of Pineal Research, 62(1). doi: 10.1111/jpi.12371.
Hu, J., Zhang, L., Yang, Y., Guo, Y., Fan, Y., Zhang, M., Man, W., Gao, E., Hu, W., Reiter, R., Wang, H., & Sun, D. (2017). Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1. Journal of Pineal Research, 62(1). doi: 10.1111/jpi.12368.