Temple University cherry "T" logo

School or College Name

Search Keywords

Sudarsan Rajan

Profile Picture of Sudarsan Rajan

Sudarsan Rajan

  • Lewis Katz School of Medicine

    • Center for Translational Medicine

      • Associate Professor

Selected Publications

Recent

  • Guo, S., Okyere, A.D., McEachern, E., Strong, J.L., Carter, R.L., Patwa, V.C., Thomas, T.P., Landy, M., Song, J., Lucchese, A.M., Martin, T.G., Gao, E., Rajan, S., Kirk, J.A., Koch, W.J., Cheung, J.Y., & Tilley, D.G. (2021). Epidermal growth factor receptor-dependent maintenance of cardiac contractility. Cardiovascular Research. doi: 10.1093/cvr/cvab149.

  • Hoffman, M., Palioura, D., Kyriazis, I., Cimini, M., Badolia, R., Rajan, S., Gao, E., Nikolaidis, N., Schulze, P., Goldberg, I., Kishore, R., Yang, V., Bannister, T., Bialkowska, A., Selzman, C., Drakos, S., & Drosatos, K. (2021). Cardiomyocyte Krüppel-Like Factor 5 Promotes de Novo Ceramide Biosynthesis and Contributes to Eccentric Remodeling in Ischemic Cardiomyopathy. Circulation, 1139-1156. doi: 10.1161/CIRCULATIONAHA.120.047420.

  • Brun, M., Song, K., Kang, B., Lueck, C., Chen, W., Thatcher, K., Gao, E., Koch, W., Lincoln, J., Rajan, S., & Suh, J. (2020). Constructing and evaluating caspase-activatable adeno-associated virus vector for gene delivery to the injured heart. Journal of Controlled Release, 328, 834-845. doi: 10.1016/j.jconrel.2020.10.058.

  • Garikipati, V., Verma, S., Cheng, Z., Liang, D., Truongcao, M., Cimini, M., Yue, Y., Huang, G., Wang, C., Benedict, C., Tang, Y., Mallaredy, V., Ibetti, J., Grisanti, L., Schumacher, S., Gao, E., Rajan, S., Wilusz, J., Goukassian, D., Houser, S., Koch, W., & Kishore, R. (2020). Author Correction: Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis (Nature Communications, (2019), 10, 1, (4317), 10.1038/s41467-019-11777-7). Nature Communications, 11(1). doi: 10.1038/s41467-020-15382-x.

  • Hoffman, M.K., Kyriazis, I., Palioura, D., Cimini, M., Rajan, S., Gao, E., Nikolaidis, N., Schulze, C., Goldberg, I.J., Kishore, R., Yang, V.W., Bannister, T., Bialkowska, A., Selzman, C., Drakos, S.G., & Drosatos, K. (2020). Abstract 17036: Cardiomyocyte Krüppel-Like Factor 5 Regulates Ceramide Biosynthesis and Promotes Systolic Dysfunction in Ischemic Heart Failure. Circulation, 142(Suppl_3). doi: 10.1161/circ.142.suppl_3.17036.

  • Tzimas, C., Russo, I., Dun, W., Yilmaz, S., Rajan, S., & Tsai, E.J. (2020). Abstract 546: S-palmitoylation Mediates Caveolae Localization and Limits Cysteine Oxidation of Gc-1 in Cardiomyocytes. Circulation Research, 127(Suppl_1). doi: 10.1161/res.127.suppl_1.546.

  • Roy, R., Shanmughapriya, S., Zhang, X., Song, J., Tomar, D., Schumacher, S.M., Gao, E., Wang, H., Cheung, J.Y., Koch, W.J., & Rajan, S. (2020). Mcur1 is a Potential Target to Modulate Cardiac Contractility and Alleviate Cardiac Function During Heart Failure. CIRCULATION RESEARCH, 127. 10.1161/res.127.suppl_1.381

  • Tzimas, C., Russo, I., Dun, W., Yilmaz, S., Rajan, S., & Tsai, E.J. (2020). S‐Palmitoylation Mediates Caveolae Localization and Limits Cysteine Oxidation of GC‐1 in Cardiomyocytes. The FASEB Journal, 34(S1), 1-1. doi: 10.1096/fasebj.2020.34.s1.09528.

  • Hoffman, M., Kyriazis, I., Lyons, W., Rajan, S., Gao, E., Khan, M., Bannister, T., Yang, V., Bialkowska, A., Selzman, C., Drakos, S., & Drosatos, K. Cardiomyocyte Kruppel-like Factor 5 Regulates Ceramide Biosynthesis and miR-30 Suppression in Ischemic Cardiomyopathy and Promotes Systolic Dysfunction. FASEB JOURNAL, 34. 10.1096/fasebj.2020.34.s1.07226

  • Garikipati, V., Verma, S., Cheng, Z., Liang, D., Truongcao, M., Cimini, M., Yue, Y., Huang, G., Wang, C., Benedict, C., Tang, Y., Mallaredy, V., Ibetti, J., Grisanti, L., Schumacher, S., Gao, E., Rajan, S., Wilusz, J., Goukassian, D., Houser, S., Koch, W., & Kishore, R. (2019). Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis. Nature Communications, 10(1). doi: 10.1038/s41467-019-11777-7.

  • Miller, B., Wang, J., Song, J., Zhang, X., Hirschler-Laszkiewicz, I., Shanmughapriya, S., Tomar, D., Rajan, S., Feldman, A., Madesh, M., Sheu, S., & Cheung, J. (2019). Trpm2 enhances physiological bioenergetics and protects against pathological oxidative cardiac injury: Role of Pyk2 phosphorylation. Journal of Cellular Physiology, 234(9), 15048-15060. doi: 10.1002/jcp.28146.

  • Cheung, J., Gordon, J., Wang, J., Song, J., Zhang, X., Prado, F., Shanmughapriya, S., Rajan, S., Tomar, D., Tahrir, F., Gupta, M., Knezevic, T., Merabova, N., Kontos, C., McClung, J., Klotman, P., Madesh, M., Khalili, K., & Feldman, A. (2019). Mitochondrial dysfunction in human immunodeficiency virus-1 transgenic mouse cardiac myocytes. Journal of Cellular Physiology, 234(4), 4432-4444. doi: 10.1002/jcp.27232.

  • Tomar, D., Jaña, F., Dong, Z., Quinn, W., Jadiya, P., Breves, S., Daw, C., Srikantan, S., Shanmughapriya, S., Nemani, N., Carvalho, E., Tripathi, A., Worth, A., Zhang, X., Razmpour, R., Seelam, A., Rhode, S., Mehta, A., Murray, M., Slade, D., Ramirez, S., Mishra, P., Gerhard, G., Caplan, J., Norton, L., Sharma, K., Rajan, S., Balciunas, D., Wijesinghe, D., Ahima, R., Baur, J., & Madesh, M. (2019). Blockade of MCU-Mediated Ca 2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation. Cell Reports, 26(13), 3709-3725.e7. doi: 10.1016/j.celrep.2019.02.107.

  • Rajan, S., Jagatheesan, G., Petrashevskaya, N., Biesiadecki, B., Warren, C., Riddle, T., Liggett, S., Wolska, B., Solaro, R., & Wieczorek, D. (2019). Tropomyosin pseudo-phosphorylation results in dilated cardiomyopathy. Journal of Biological Chemistry, 294(8), 2913-2923. doi: 10.1074/jbc.RA118.004879.

  • Shanmughapriya, S., Tomar, D., Dong, Z., Slovik, K., Nemani, N., Natarajaseenivasan, K., Carvalho, E., Lu, C., Corrigan, K., Garikipati, V., Ibetti, J., Rajan, S., Barrero, C., Chuprun, K., Kishore, R., Merali, S., Tian, Y., Yang, W., & Madesh, M. (2018). FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation. Nature Communications, 9(1). doi: 10.1038/s41467-018-05856-4.

  • Lee, H., Kim, K., Kim, B., Shin, J., Rajan, S., Wu, J., Chen, X., Brown, M., Lee, S., & Park, J. (2018). A cellular mechanism of muscle memory facilitates mitochondrial remodelling following resistance training. Journal of Physiology, 596(18), 4413-4426. doi: 10.1113/JP275308.

  • Tomar, D., Shanmughapriya, S., Roy, R., Zhang, X., Song, J., Schumacher, S.M., Madesh, M., Cheung, J.Y., Koch, W.J., & Rajan, S. (2018). The Role of Mitochondrial Calcium Uniporter Complex in Cardiac Contractility and Function. CIRCULATION RESEARCH, 123. 10.1161/res.123.suppl_1.366

  • Garikipati, V.N., Verma, S.K., Cheng, Z., Liang, D., Truongcao, M.M., Cimini, M., Wang, C., Benedict, C., Ibetti, J., Grisanti, L., Schumacher, S.M., Gao, E., Rajan, S., Wilusz, J.E., Goukassian, D., Houser, S., Koch, W.J., & Kishore, R. (2018). Abstract 288: Circular RNA CircFNDC3b Modulates Cardiac Repair After Myocardial Infarction via FUS-1/VEGF-A Axis. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.288.

  • Nemani, N., Carvalho, E., Tomar, D., Dong, Z., Ketschek, A., Breves, S., Jaña, F., Worth, A., Heffler, J., Palaniappan, P., Tripathi, A., Subbiah, R., Riitano, M., Seelam, A., Manfred, T., Itoh, K., Meng, S., Sesaki, H., Craigen, W., Rajan, S., Shanmughapriya, S., Caplan, J., Prosser, B., Gill, D., Stathopulos, P., Gallo, G., Chan, D., Mishra, P., & Madesh, M. (2018). MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca2+ Stress. Cell Reports, 23(4), 1005-1019. doi: 10.1016/j.celrep.2018.03.098.

  • Seki, M., Powers, J., Maruyama, S., Zuriaga, M., Wu, C., Kurishima, C., Kim, L., Johnson, J., Poidomani, A., Wang, T., Muñoz, E., Rajan, S., Park, J., Walsh, K., & Recchia, F. (2018). Acute and chronic increases of circulating FSTL1 normalize energy substrate metabolism in pacing-induced heart failure. Circulation: Heart Failure, 11(1). doi: 10.1161/CIRCHEARTFAILURE.117.004486.

  • Michael, J., Wurtzel, J., Mao, G., Rao, A., Kolpakov, M., Sabri, A., Hoffman, N., Rajan, S., Tomar, D., Madesh, M., Nieman, M., Yu, J., Edelstein, L., Rowley, J., Weyrich, A., & Goldfinger, L. (2017). Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth. Blood, 130(5), 567-580. doi: 10.1182/blood-2016-11-751099.

  • Rajan, S., Shanmughapriya, S., Tomar, D., Dong, Z., Cheung, J.Y., Stathopulos, P.B., & Muniswamy, M. (2017). Abstract 125: Perturbation of Mitochondrial Calcium Uniporter Promotes Cardiac Oxidative Stress and Autophagy During Heart Failure. Circulation Research, 121(suppl_1). doi: 10.1161/res.121.suppl_1.125.

  • Dong, Z., Shanmughapriya, S., Tomar, D., Siddiqui, N., Lynch, S., Nemani, N., Breves, S., Zhang, X., Tripathi, A., Palaniappan, P., Riitano, M., Worth, A., Seelam, A., Carvalho, E., Subbiah, R., Jaña, F., Soboloff, J., Peng, Y., Cheung, J., Joseph, S., Caplan, J., Rajan, S., Stathopulos, P., & Madesh, M. (2017). Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity. Molecular Cell, 65(6), 1014-1028.e7. doi: 10.1016/j.molcel.2017.01.032.