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Walter J Koch

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Walter J Koch

  • Lewis Katz School of Medicine

    • Center for Translational Medicine

      • Professor

    • Pharmacology

      • William Wikoff Smith Endowed Chair in Cardiovascular Medicine

Research Interests

  • The Koch laboratory currently is investigating molecular mechanisms involved in the regulation of signaling through cardiovascular adrenergic receptors (ARs) and the role this plays in heart disease
  • primarily heart failure (HF). The lab s research primarily targets a family of kinases known to regulate ARs and other G protein-coupled receptors (GPCRs) known as the GPCR kinases (GRKs). These GRKs appear to be critically involved in normal and failing heart function and we are manipulating the expression and activity of GRKs in the cardiovascular system. To do this
  • we utilize novel genetically engineered mouse models and also adenoviral-mediated myocardial gene delivery. Signaling information delineated to be involved in the pathogenesis of heart disease is utilized to design potential novel molecular therapeutic strategies for heart disease. This includes an ultimate goal of the laboratory to develop gene therapy protocols for HF utilizing novel intracoronary delivery techniques. These delivery techniques as well as "proof of concept" testing of molecular targets in the heart are currently being carried out in vivo in models of HF. In addition to HF
  • programs are ongoing in the laboratory to investigate novel ways to protect the heart against ischemia-induced myocyte apoptosis and also molecular ways to improve the function of the transplanted human heart. Another program in the lab is the investigation of the role of GPCR signaling in pathological vascular smooth muscle proliferation such as what occurs during arterial restenosis following angioplasty. New directions in the lab have us interested in novel non-GPCR binding partners for GRKs and are using a variety of in vitro techniques to discover and investigate these with a future plan to determine any cardiovascular physiological relevance of these GRK targets.

Selected Publications

Recent

  • Zhong, C., Min, K., Zhao, Z., Zhang, C., Gao, E., Huang, Y., Zhang, X., Baldini, M., Roy, R., Yang, X., Koch, W.J., Bennett, A.M., & Yu, J. (2021). MAP Kinase Phosphatase-5 Deficiency Protects Against Pressure Overload-Induced Cardiac Fibrosis. Frontiers in Immunology, 12, 790511. doi: 10.3389/fimmu.2021.790511.

  • Gan, L., Liu, D., Xie, D., Lau, W.B., Liu, J., Christopher, T.A., Lopez, B., Liu, L., Hu, H., Yao, P., He, Y., Gao, E., Koch, W.J., Zhao, J., Ma, X., Cao, Y., & Wang, Y. (2021). Ischemic Heart-Derived Small Extracellular Vesicles Impair Adipocyte Function. Circulation Research. doi: 10.1161/circresaha.121.320157.

  • Yuko, A., Rigaud, V.C., Kurian, J., Lee, J., Kasatkin, N., Behanan, M., Wang, T., Luchesse, A., Mohsin, S., Koch, W., Wang, H., & Khan, M. (2021). LIN28a induced metabolic and redox regulation promotes cardiac cell survival in the heart after ischemic injury. Redox Biology, 47. doi: 10.1016/j.redox.2021.102162.

  • Marzano, F., Rapacciuolo, A., Koch, W.J., & Cannavo, A. (2021). Abstract P426: Inactivating Grk5 Impairs Basal Cardiac Function And Survival Via P53 Modulation. Circulation Research, 129(Suppl_1). doi: 10.1161/res.129.suppl_1.p426.

  • Gurrala, C.T., Garikipati, V., Cheng, Z., Mallaredy, V., Cimini, M., Joladarashi, D., TRUONGCAO, M., Wang, C., Huang, G., Gonzalez, C., Magadum, A., Roy, R., Benedict, C., Koch, W.J., & Kishore, R. (2021). Abstract P375: Gender-based Cardio-protective Functional Dimorphism Of Bone Marrow Endothelial Progenitor Cells And Their Exosomes: Estrogen-independent Epigenetic Mechanisms. Circulation Research, 129(Suppl_1). doi: 10.1161/res.129.suppl_1.p375.

  • Ferrero, K., Pfleger, J.M., Chuprun, K., Barr, E., Gao, E., & Koch, W.J. (2021). Abstract MP247: Mitochondrial Complex V Is Regulated By GRK2 In The Heart. Circulation Research, 129(Suppl_1). doi: 10.1161/res.129.suppl_1.mp247.

  • Schumacher, S., Bledzka, K., Manaserh, I., Grondolsky, J., Roy, R., Gao, E., & Koch, W. (2021). Enhanced insulin‐responsive AS160 elicits cardioprotection during metabolic stress. The FASEB Journal, 35(S1). doi: 10.1096/fasebj.2021.35.s1.00202.

  • Bledzka, K.M., Manserh, I., Wagoner, D.V., Koch, W., & Schumacher, S. (2021). Identifying Sex‐dependent Markers of Heart Failure and Atrial Myopathy. The FASEB Journal, 35(S1). doi: 10.1096/fasebj.2021.35.s1.04633.

  • Marzano, F., Rapacciuolo, A., Koch, W., & Cannavo, A. (2021). GRK5‐Dependent p53 Activity Controls Basal Cardiac Function and Survival. The FASEB Journal, 35(S1). doi: 10.1096/fasebj.2021.35.s1.02884.

  • Liu, D., Gu, G., Gan, L., Yan, W., Zhang, Z., Yao, P., Zhu, D., Lau, W., Xie, D., Wu, S., Meng, Z., Tsukuda, J., Christopher, T., Lopez, B., Zhao, J., Gao, E., Koch, W., Ma, X., & Wang, Y. (2021). Identification of a CTRP9 C-Terminal polypeptide capable of enhancing bone-derived mesenchymal stem cell cardioprotection through promoting angiogenic exosome production. Redox Biology, 41. doi: 10.1016/j.redox.2021.101929.

  • Bledzka, K., Manaserh, I., Grondolsky, J., Pfleger, J., Roy, R., Gao, E., Chuprun, J., Koch, W., & Schumacher, S. (2021). A peptide of the amino-terminus of GRK2 induces hypertrophy and yet elicits cardioprotection after pressure overload. Journal of Molecular and Cellular Cardiology, 154, 137-153. doi: 10.1016/j.yjmcc.2021.01.004.

  • Kwon, J., Barr, E., Chuprun, J., & Koch, W. (2021). In vivo stimulation of α-and β-adrenoceptors in mice differentially alters small rna content of circulating extracellular vesicles. Cells, 10(5). doi: 10.3390/cells10051211.

  • Guo, S., Okyere, A.D., McEachern, E., Strong, J.L., Carter, R.L., Patwa, V.C., Thomas, T.P., Landy, M., Song, J., Lucchese, A.M., Martin, T.G., Gao, E., Rajan, S., Kirk, J.A., Koch, W.J., Cheung, J.Y., & Tilley, D.G. (2021). Epidermal growth factor receptor-dependent maintenance of cardiac contractility. Cardiovascular Research. doi: 10.1093/cvr/cvab149.

  • Roy, R. & Koch, W. (2021). Adding another GRK to the fire of heart failure. European Heart Journal, 42(14), 1431-1432. doi: 10.1093/eurheartj/ehaa847.

  • Kwon, J., Schumacher, S., Gao, E., Chuprun, J., Ibetti, J., Roy, R., Khan, M., Kishore, R., & Koch, W. (2021). Characterization of βaRKct engineered cellular extracellular vesicles and model specific cardioprotection. American Journal of Physiology - Heart and Circulatory Physiology, 320(4), H1276-H1289. doi: 10.1152/AJPHEART.00571.2020.

  • Coleman, R., Eguchi, A., Lieu, M., Roy, R., Barr, E., Ibetti, J., Lucchese, A., Peluzzo, A., Gresham, K., Chuprun, J., & Koch, W. (2021). A peptide of the N terminus of GRK5 attenuates pressure-overload hypertrophy and heart failure. Science Signaling, 14(676). doi: 10.1126/scisignal.abb5968.

  • Piedepalumbo, M., Koch, W., & Lucia, C.d. (2021). Metabolomics, heart disease and aging. Aging, 13(5), 6231-6232. doi: 10.18632/aging.202804.

  • Lucia, C.d., Grisanti, L.A., Borghetti, G., Piedepalumbo, M., Ibetti, J., Lucchese, A.M., Barr, E.W., Roy, R., Okyere, A.D., Murphy, H.C., Gao, E., Rengo, G., Houser, S.R., Tilley, D.G., & Koch, W.J. (2021). GRK5 contributes to impaired cardiac function and immune cell recruitment in post-ischemic heart failure. Cardiovascular Research, cvab044-. doi: 10.1093/cvr/cvab044.

  • Eguchi, A., Coleman, R., Gresham, K., Gao, E., Ibetti, J., Chuprun, J., & Koch, W. (2021). GRK5 is a regulator of fibroblast activation and cardiac fibrosis. Proceedings of the National Academy of Sciences of the United States of America, 118(5). doi: 10.1073/pnas.2012854118.

  • Marzano, F., Rapacciuolo, A., Ferrara, N., Rengo, G., Koch, W., & Cannavo, A. (2021). Targeting GRK5 for treating chronic degenerative diseases. International Journal of Molecular Sciences, 22(4), 1-17. doi: 10.3390/ijms22041920.

  • Koch, W., Vagnozzi, R., Wang, T., Liao, R., & Houser, S. (2021). Thomas L. Force, MD: 1951-2020: A Brilliant Physician-Scientist Gone Too Soon. Circulation Research, 128(1), 6-7. doi: 10.1161/CIRCRESAHA.120.318673.

  • Kayki-Mutlu, G. & Koch, W. (2021). Nitric oxide and s-nitrosylation in cardiac regulation: G protein-coupled receptor kinase-2 and β-arrestins as targets. International Journal of Molecular Sciences, 22(2), 1-17. doi: 10.3390/ijms22020521.

  • Kyriazis, I., Hoffman, M., Gaignebet, L., Lucchese, A., Markopoulou, E., Palioura, D., Wang, C., Bannister, T., Christofidou-Solomidou, M., Oka, S., Sadoshima, J., Koch, W., Goldberg, I., Yang, V., Bialkowska, A., Kararigas, G., & Drosatos, K. (2021). KLF5 is induced by FOXO1 and causes oxidative stress and diabetic cardiomyopathy. Circulation Research, 335-357. doi: 10.1161/CIRCRESAHA.120.316738.

  • Lucia, C.d., Piedepalumbo, M., Wang, L., Neto, F.C., Raftery, D., Gao, E., Praticò, D., Promislow, D., & Koch, W. (2021). Effects of myocardial ischemia/reperfusion injury on plasma metabolomic profile during aging. Aging Cell, 20(1). doi: 10.1111/acel.13284.

  • Yusuf, A., Qaisar, R., Al-Tamimi, A., Jayakumar, M., Woodgett, J., Koch, W., & Ahmad, F. (2021). Cardiomyocyte-GSK-3β deficiency induces cardiac progenitor cell proliferation in the ischemic heart through paracrine mechanisms. Journal of Cellular Physiology. doi: 10.1002/jcp.30644.

  • Brun, M., Song, K., Kang, B., Lueck, C., Chen, W., Thatcher, K., Gao, E., Koch, W., Lincoln, J., Rajan, S., & Suh, J. (2020). Constructing and evaluating caspase-activatable adeno-associated virus vector for gene delivery to the injured heart. Journal of Controlled Release, 328, 834-845. doi: 10.1016/j.jconrel.2020.10.058.

  • Garikipati, V., Verma, S., Cheng, Z., Liang, D., Truongcao, M., Cimini, M., Yue, Y., Huang, G., Wang, C., Benedict, C., Tang, Y., Mallaredy, V., Ibetti, J., Grisanti, L., Schumacher, S., Gao, E., Rajan, S., Wilusz, J., Goukassian, D., Houser, S., Koch, W., & Kishore, R. (2020). Author Correction: Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis (Nature Communications, (2019), 10, 1, (4317), 10.1038/s41467-019-11777-7). Nature Communications, 11(1). doi: 10.1038/s41467-020-15382-x.

  • Ferrero, K.M., Mutlu, G.K., Pfleger, J.M., Tilley, D.G., & Koch, W.J. (2020). Abstract 17473: GRK2 in the Mitochondria: Uncovering Novel Mechanisms in Heart Failure. Circulation, 142(Suppl_3). doi: 10.1161/circ.142.suppl_3.17473.

  • Kyriazis, I.D., Hoffman, M.K., Gaignebet, L., Lucchese, A.M., Wang, C., Bannister, T., Christofidou-Solomidou, M., Oka, S., Sadoshima, J., Koch, W.J., Goldberg, I.J., Yang, V.W., Bialkowska, A., Kararigas, G., & Drosatos, K. (2020). Abstract 16563: FOXO1 Induces Cardiomyocyte-KLF5, Which Drives Oxidative Stress and Diabetic Cardiomyopathy. Circulation, 142(Suppl_3). doi: 10.1161/circ.142.suppl_3.16563.

  • Huang, G., Garikipati, V., Zhou, Y., Benedict, C., Houser, S., Koch, W., & Kishore, R. (2020). Identification and Comparison of Hyperglycemia-Induced Extracellular Vesicle Transcriptome in Different Mouse Stem Cells. Cells, 9(9). doi: 10.3390/cells9092098.

  • Marzano, F., Liccardo, D., Koch, W.J., Rengo, G., & Cannavo, A. (2020). GRK2 downstream aldosterone and mineralocorticoid receptor system induces cardiac insulin-resistance and β-adrenergic dysfunction. Vascular Pharmacology, 132, 106737. doi: 10.1016/j.vph.2020.106737.

  • Kwon, J.S., Gao, E., Roy, R., Ibetti, j., Chuprun, J.K., & Koch, W.J. (2020). Abstract 475: Beta-adrenoceptor Stimulation Uniquely Regulates Exosome Micro-rna Content Secreted From Cardiomyocytes in vitro and Those Found in vivo Circulating in Blood. Circulation Research, 127(Suppl_1). doi: 10.1161/res.127.suppl_1.475.

  • Mutlu, G.K., Ferrero, K., Roy, R., Lucchese, A.M., Gao, E., & Koch, W.J. (2020). Abstract MP122: Effects of Cardiac Beta3-Adrenoceptors on the Inhibition of G Protein-coupled Receptor Kinase 2 via S-nitrosylation. Circulation Research, 127(Suppl_1). doi: 10.1161/res.127.suppl_1.mp122.

  • Jun, S., Agrimi, J., Cannavo, A., Keceli, G., Oeing, C.U., Eremiev, A., Marcucci, L., Megighian, A., RENGO, G., Koch, W.J., & Paolocci, N. (2020). Abstract 340: Myocyte-borne Bdnf is Essential to Limit Post-ischemic Cardiac Injury and Dysfunction. Circulation Research, 127(Suppl_1). doi: 10.1161/res.127.suppl_1.340.

  • Cheng, Z., Truongcao, M.M., Wang, C., Garikipati, V.N., Tang, Y., Cimini, M., Benedict, C., Huang, G., Mallaredy, V., Goukassian, D., Verma, S.K., Koch, W.J., & Kishore, R. (2020). Abstract 249: Plasma Exosomes Impair Angiogenesis in Ischemic Hind Limb of Diabetic Mice- Role of Histone Methylation. Circulation Research, 127(Suppl_1). doi: 10.1161/res.127.suppl_1.249.

  • Lieu, M., Traynha, C., Lucia, C.D., Pfleger, J., Piedepalumbo, M., Roy, R., Petovic, J., Landesberg, G., Forreste, S., Hoffman, M., Grisant, L., Yuan, A., Gao, E., Drosatos, K., Eguchi, S., Scalia, R., Tille, D., & Koc, W. (2020). Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging. American Journal of Physiology - Heart and Circulatory Physiology, 318(5), H1162-H1175. doi: 10.1152/ajpheart.00094.2020.

  • Hoffman, M., Kyriazis, I., Dimitriou, A., Mishra, S., Koch, W., & Drosatos, K. (2020). B-type natriuretic peptide is upregulated by c-Jun N-terminal kinase and contributes to septic hypotension. JCI Insight, 5(8). doi: 10.1172/jci.insight.133675.

  • Wang, Y., Liu, D., Zhu, D., Lau, W.B., Lopez, B., Christopher, T., Xie, D., Zhang, Z., Gao, E., Koch, W., & Ma, X. (2020). Identification of a CTRP9 Fragment Capable of Enhancing Bone Marrow Mesenchymal Stem Cell Cardioprotection via Cardioreparative Exosome Production Promotion. The FASEB Journal, 34(S1), 1-1. doi: 10.1096/fasebj.2020.34.s1.03929.

  • Du, Y., Wang, X., Lau, W.B., Wei, Y., Liu, H., Du, J., Yin, L., Gao, E., Koch, W., Wang, Y., & Ma, X. (2020). Adiponectin improves vascular endothelial dysfunction through caveolin-1 mediated nuclear translocation and HDAC inhibition. Journal of Molecular and Cellular Cardiology, 140, 56-57. doi: 10.1016/j.yjmcc.2019.11.136.

  • Pfleger, J., Coleman, R., Ibetti, J., Roy, R., Kyriazis, I., Gao, E., Drosatos, K., & Koch, W. (2020). Genomic binding patterns of forkhead box protein O1 reveal its unique role in cardiac hypertrophy. Circulation, 882-898. doi: 10.1161/CIRCULATIONAHA.120.046356.

  • Yue, Y., Wang, C., Benedict, C., Huang, G., Truongcao, M., Roy, R., Cimini, M., Garikipati, V., Cheng, Z., Koch, W., & Kishore, R. (2020). Interleukin-10 Deficiency Alters Endothelial Progenitor Cell-Derived Exosome Reparative Effect on Myocardial Repair via Integrin-Linked Kinase Enrichment. Circulation Research, 315-329. doi: 10.1161/CIRCRESAHA.119.315829.

  • Gan, L., Xie, D., Liu, J., Lau, W.B., Christopher, T., Lopez, B., Zhang, L., Gao, E., Koch, W., Ma, X., & Wang, Y. (2020). Small Extracellular Microvesicles Mediated Pathological Communications between Dysfunctional Adipocytes and Cardiomyocytes as a Novel Mechanism Exacerbating Ischemia/Reperfusion Injury in Diabetic Mice. Circulation, 968-983. doi: 10.1161/CIRCULATIONAHA.119.042640.

  • Ferrero, K. & Koch, W. (2020). Metabolic crosstalk between the heart and fat. Korean Circulation Journal, 50(5), 379-394. doi: 10.4070/kcj.2019.0400.

  • Garikipati, V., Verma, S., Cheng, Z., Liang, D., Truongcao, M., Cimini, M., Yue, Y., Huang, G., Wang, C., Benedict, C., Tang, Y., Mallaredy, V., Ibetti, J., Grisanti, L., Schumacher, S., Gao, E., Rajan, S., Wilusz, J., Goukassian, D., Houser, S., Koch, W., & Kishore, R. (2019). Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis. Nature Communications, 10(1). doi: 10.1038/s41467-019-11777-7.

  • Pfleger, J., Gresham, K., & Koch, W. (2019). G protein-coupled receptor kinases as therapeutic targets in the heart. Nature Reviews Cardiology, 16(10), 612-622. doi: 10.1038/s41569-019-0220-3.

  • Cimini, M., Garikipati, V.S., Lucia, C.d., Cheng, Z., Wang, C., Truongcao, M., Lucchese, A., Roy, R., Benedict, C., Goukassian, D., Koch, W., & Kishore, R. (2019). Podoplanin neutralization improves cardiac remodeling and function after myocardial infarction. JCI Insight, 4(15). doi: 10.1172/jci.insight.126967.

  • Beyett, T., Fraley, A., Labudde, E., Patra, D., Coleman, R., Eguchi, A., Glukhova, A., Chen, Q., Williams, R., Koch, W., Sherman, D., & Tesmer, J. (2019). Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe. Proceedings of the National Academy of Sciences of the United States of America, 116(32), 15895-15900. doi: 10.1073/pnas.1818547116.

  • Gan, L., Xie, D., Lau, W., Christopher, T., Lopez, B., Zhang, L., Liu, J., Gao, E., Koch, W., Wang, Y., & Ma, X. (2019). Abstract 646: Myocardial Ischemia/Reperfusion Impairs Adipocyte Endocrine Function via Exosome-Mediated Endoplasmic Reticulum Dysfunction. Circulation Research, 125(Suppl_1). doi: 10.1161/res.125.suppl_1.646.

  • Lieu, M., Traynham, C.J., Petovic, J., Landesberg, G.P., Forrester, S., Gao, E., Eguchi, S., Scalia, R., & Koch, W.J. (2019). Abstract 841: Loss of S-nitrosylation of G Protein-Coupled Receptor Kinase 2 Leads to Cardiovascular Dysfunction With Aging. Circulation Research, 125(Suppl_1). doi: 10.1161/res.125.suppl_1.841.

  • Okyere, A.D., Lucia, C.d., Song, J., Carter, R.L., Benovic, J.L., Koch, W.J., Cheung, J.Y., & Tilley, D.G. (2019). Abstract 757: β-arrestin-Biased β2-Adrenergic Receptor Signaling Mediates Novel Mechanisms of Cardiomyocyte Contractility. Circulation Research, 125(Suppl_1). doi: 10.1161/res.125.suppl_1.757.

  • Kwon, J. & Koch, W.J. (2019). Abstract 606: Stimulation of Cardiomyocyte a- and b-Adrenoceptors Uniquely Regulates Exosome Generation and miRNA Content. Circulation Research, 125(Suppl_1). doi: 10.1161/res.125.suppl_1.606.

  • Eguchi, A. & Koch, W.J. (2019). Abstract 516: GRK5 Regulates Cardiac Fibroblast Differentiation and Fibrosis. Circulation Research, 125(Suppl_1). doi: 10.1161/res.125.suppl_1.516.

  • Gresham, K.S. & Koch, W.J. (2019). Abstract 277: Neonatal Cardiomyocyte-Released Signaling Protein Reduces Adipocyte Differentiation. Circulation Research, 125(Suppl_1). doi: 10.1161/res.125.suppl_1.277.

  • Coleman, R., Barr, E.W., Chuprun, K., & Koch, W.J. (2019). Abstract 917: Actively Blocking Nuclear Localization of G Protein-Couple Receptor 5 Blunts Hypertrophy and Heart Failure After TAC. Circulation Research, 125(Suppl_1). doi: 10.1161/res.125.suppl_1.917.

  • Bledzka, K.M., Manaserh, I.H., Koch, W.J., Grondolsky, J., & Schumacher, S.M. (2019). Abstract 258: Elucidating Sex Differences in Stress-related Atrial Remodeling and AF Risk in a Mouse Model of Atrial Dysfunction. Circulation Research, 125(Suppl_1). doi: 10.1161/res.125.suppl_1.258.

  • Waldschmidt, H., Homan, K., Cato, M., Cruz-Rodríguez, O., Cannavo, A., Wilson, M., Song, J., Cheung, J., Koch, W., Tesmer, J., & Larsen, S. (2019). Correction to: Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine (Journal of Medicinal Chemistry (2017) 60:7 (3052-3069) DOI: 10.1021/acs.jmedchem.7b00112). Journal of Medicinal Chemistry, 62(12), 5920. doi: 10.1021/acs.jmedchem.9b00844.

  • Hoffman, M., Kyriazis, I., Lucchese, A., Lucia, C.d., Piedepalumbo, M., Bauer, M., Schulze, P., Bonios, M., Koch, W., & Drosatos, K. (2019). Myocardial Strain and Cardiac Output are Preferable Measurements for Cardiac Dysfunction and Can Predict Mortality in Septic Mice. Journal of the American Heart Association, 8(10). doi: 10.1161/JAHA.119.012260.

  • LaCanna, R., Liccardo, D., Zhang, P., Tragesser, L., Wang, Y., Cao, T., Chapman, H., Morrisey, E., Shen, H., Koch, W., Kosmider, B., Wolfson, M., & Tian, Y. (2019). Yap/Taz regulate alveolar regeneration and resolution of lung inflammation. Journal of Clinical Investigation, 129(5), 2107-2122. doi: 10.1172/JCI125014.

  • Lucia, C.d., Grisanti, L.A., Borghetti, G., Ibetti, J., Lucchese, A.M., Gao, E., Rengo, G., Houser, S.R., Tilley, D., & Koch, W.J. GRK5-mediated Exacerbation of Ischemic Heart Failure Involves Cardiac Immune and Inflammatory Responses. FASEB JOURNAL, 33. Retrieved from http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000496555200461&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=abcd71df5a6dac31fd219478b0a9c638.

  • Wang, Y., Gan, L., Xie, D., Lau, W.B., Liu, J., Zhang, L., Gao, E., Koch, W., & Ma, X. (2019). Exosome Mediated Globular Adiponectin's Cardioprotective Role via the Adiponectin receptor‐dependent Uptake mechanism. The FASEB Journal, 33(S1), 833.21-833.21. doi: 10.1096/fasebj.2019.33.1_supplement.833.21.

  • Desimine, V.L., Parker, B.M., Wertz, S.L., Duarte, Y., Maning, J., McCrink, K.A., Pollard, C.M., Koch, W.J., & Lymperopoulos, A. (2019). GRK5‐mediated inhibitory phosphorylation is essential for inverse agonism at the cardiac mineralocorticoid receptor. The FASEB Journal, 33(S1), 676.8-676.8. doi: 10.1096/fasebj.2019.33.1_supplement.676.8.

  • Cannavo, A., Liccardo, D., Lymperopoulos, A., Gambino, G., D’Amico, M., Rengo, F., Koch, W., Leosco, D., Ferrara, N., & Rengo, G. (2019). Correction to :β adrenergic receptor kinase C-terminal peptide gene-therapy improves ß2-adrenergic receptor-dependent neoangiogenesis after hindlimb ischemia (Journal of Pharmacology and Experimental Therapeutics (2016) 356:2 (503–513) DOI: 10.1124/jpet.115.228411). Journal of Pharmacology and Experimental Therapeutics, 369(1), 65. doi: 10.1124/jpet.115.228411err.

  • Lucia, C.D., Wallner, M., Eaton, D., Zhao, H., Houser, S., & Koch, W. (2019). Echocardiographic Strain Analysis for the Early Detection of Left Ventricular Systolic/Diastolic Dysfunction and Dyssynchrony in a Mouse Model of Physiological Aging. Journals of Gerontology - Series a Biological Sciences and Medical Sciences, 74(4), 455-461. doi: 10.1093/gerona/gly139.

  • Magga, J., Vainio, L., Kilpiö, T., Hulmi, J., Taponen, S., Lin, R., Räsänen, M., Szabó, Z., Gao, E., Rahtu-Korpela, L., Alakoski, T., Ulvila, J., Laitinen, M., Pasternack, A., Koch, W., Alitalo, K., Kivelä, R., Ritvos, O., & Kerkelä, R. (2019). Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury. Molecular Therapy, 27(3), 600-610. doi: 10.1016/j.ymthe.2019.01.013.

  • Lieu, M. & Koch, W. (2019). GRK2 and GRK5 as therapeutic targets and their role in maladaptive and pathological cardiac hypertrophy. Expert Opinion on Therapeutic Targets, 23(3), 201-214. doi: 10.1080/14728222.2019.1575363.

  • Lucia, C.d., Piedepalumbo, M., Paolisso, G., & Koch, W. (2019). Sympathetic nervous system in age-related cardiovascular dysfunction: Pathophysiology and therapeutic perspective. International Journal of Biochemistry and Cell Biology, 108, 29-33. doi: 10.1016/j.biocel.2019.01.004.

  • Bauer, R., Enns, H., Jungmann, A., Leuchs, B., Volz, C., Schinkel, S., Koch, W., Raake, P., Most, P., Katus, H., & Müller, O. (2019). Various effects of AAV9-mediated βARKct gene therapy on the heart in dystrophin-deficient (mdx) mice and δ-sarcoglycan-deficient (Sgcd-/-) mice. Neuromuscular Disorders, 29(3), 231-241. doi: 10.1016/j.nmd.2018.12.006.

  • Vainio, L., Szabó, Z., Lin, R., Ulvila, J., Yrjölä, R., Alakoski, T., Piuhola, J., Koch, W., Ruskoaho, H., Fouse, S., Seeley, T., Gao, E., Signore, P., Lipson, K., Magga, J., & Kerkelä, R. (2019). Connective Tissue Growth Factor Inhibition Enhances Cardiac Repair and Limits Fibrosis After Myocardial Infarction. JACC: Basic to Translational Science, 4(1), 83-94. doi: 10.1016/j.jacbts.2018.10.007.

  • Kokkinaki, D., Hoffman, M., Kalliora, C., Kyriazis, I., Maning, J., Lucchese, A., Shanmughapriya, S., Tomar, D., Park, J., Wang, H., Yang, X., Madesh, M., Lymperopoulos, A., Koch, W., Christofidou-Solomidou, M., & Drosatos, K. (2019). Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy. Journal of Molecular and Cellular Cardiology, 127, 232-245. doi: 10.1016/j.yjmcc.2018.12.016.

  • Zhang, H., Chen, X., Gao, E., MacDonnell, S., Wang, W., Kolpakov, M., Nakayama, H., Zhang, X., Jaleel, N., Harris, D., Li, Y., Tang, M., Berretta, R., Leri, A., Kajstura, J., Sabri, A., Koch, W., Molkentin, J., & Houser, S. (2019). Expression of Concern: Increasing cardiac contractility after myocardial infarction exacerbates cardiac injury and pump dysfunction (Circulation Research (2010) 107 (800-809) DOI: 10.1161/CIRCRESAHA.110.219220). Circulation Research, 124(2), e4-e5. doi: 10.1161/RES.0000000000000241.

  • Berry, J., Zhu, W., Tang, Y., Krishnamurthy, P., Ge, Y., Cooke, J., Chen, Y., Garry, D., Yang, H., Rajasekaran, N., Koch, W., Li, S., Domae, K., Qin, G., Cheng, K., Kamp, T., Ye, L., Hu, S., Ogle, B., Rogers, J., Abel, E., Davis, M., Prabhu, S., Liao, R., Pu, W., Wang, Y., Ping, P., Bursac, N., Vunjak-Novakovic, G., Wu, J., Bolli, R., Menasché, P., & Zhang, J. (2019). Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. Circulation Research, 124(1), 161-169. doi: 10.1161/CIRCRESAHA.118.314216.

  • Grisanti, L., Lucia, C.D., Thomas, T., Stark, A., Strony, J., Myers, V., Beretta, R., Yu, D., Sardu, C., Marfella, R., Gao, E., Houser, S., Koch, W., Hamad, E., & Tilley, D. (2019). Prior beta blocker treatment decreases leukocyte responsiveness to injury. JCI Insight, 4(9). doi: 10.1172/jci.insight.99485.

  • Borden, A., Kurian, J., Nickoloff, E., Yang, Y., Troupes, C., Ibetti, J., Lucchese, A., Gao, E., Mohsin, S., Koch, W., Houser, S., Kishore, R., & Khan, M. (2019). Transient introduction of miR-294 in the heart promotes cardiomyocyte cell cycle reentry after injury. Circulation Research, 125(1), 14-25. doi: 10.1161/CIRCRESAHA.118.314223.

  • Cannavo, A., Marzano, F., Elia, A., Liccardo, D., Bencivenga, L., Gambino, G., Perna, C., Rapacciuolo, A., Cittadini, A., Ferrara, N., Paolocci, N., Koch, W., & Rengo, G. (2019). Aldosterone Jeopardizes Myocardial Insulin and β-Adrenergic Receptor Signaling via G Protein-Coupled Receptor Kinase 2. Frontiers in Pharmacology, 10(JULY). doi: 10.3389/fphar.2019.00888.

  • Woodall, B., Gresham, K., Woodall, M., Valenti, M., Cannavo, A., Pfleger, J., Chuprun, J., Drosatos, K., & Koch, W. (2019). Alteration of myocardial GRK2 produces a global metabolic phenotype. JCI Insight, 4(10). doi: 10.1172/jci.insight.123848.

  • Cannavo, A., Elia, A., Liccardo, D., Rengo, G., & Koch, W. (2019). Aldosterone and Myocardial Pathology. In Vitamins and Hormones, 109 (pp. 387-406). doi: 10.1016/bs.vh.2018.09.005.

  • Chakhtoura, M., Chain, R., Sato, P., Qiu, C., Lee, M., Meissler, J., Eisenstein, T., Koch, W., Caricchio, R., & Gallucci, S. (2019). Ethyl pyruvate modulates murine dendritic cell activation and survival through their immunometabolism. Frontiers in Immunology, 10(JAN). doi: 10.3389/fimmu.2019.00030.

  • Sato, P., Chuprun, J.K., Grisanti, L., Woodall, M., Brown, B., Roy, R., Traynham, C., Ibetti, J., Lucchese, A., Yuan, A., Drosatos, K., Tilley, D., Gao, E., & Koch, W. (2018). Restricting mitochondrial GRK2 post-ischemia confers cardioprotection by reducing myocyte death and maintaining glucose oxidation. Science Signaling, 11(560). doi: 10.1126/scisignal.aau0144.

  • Pfleger, J.M., Gross, P., Johnson, J., Gao, E., Houser, S.R., & Koch, W.J. G Protein-coupled receptor kinase 2 impairs fatty acid metabolism in the failing heart through novel mechanisms. JOURNAL of MOLECULAR and CELLULAR CARDIOLOGY, 124, 100-100. 10.1016/j.yjmcc.2018.07.055

  • Pfleger, J., Gross, P., Johnson, J., Carter, R., Gao, E., Tilley, D., Houser, S., & Koch, W. (2018). G protein-coupled receptor kinase 2 contributes to impaired fatty acid metabolism in the failing heart. Journal of Molecular and Cellular Cardiology, 123, 108-117. doi: 10.1016/j.yjmcc.2018.08.025.

  • Lucia, C.d., Eguchi, A., & Koch, W. (2018). New insights in cardiac β-Adrenergic signaling during heart failure and aging. Frontiers in Pharmacology, 9(AUG). doi: 10.3389/fphar.2018.00904.

  • Cheng, Z., Garikipati, V.N.S., Cimini, M., Tang, Y., Wang, C., Trungcao, M., Ye, Y., Benedict, C., Mallaredy, V., Koch, W., Verma, S.K., Goukassian, D., & Kishore, R. (2018). Abstract 330: Systemic Blocking Exosome Formation/Release Improves Ischemic Hindlimb Repair in Diabetic db/db Mice. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.330.

  • Garikipati, V.N., Cimini, M., Wang, C., Roy, R., Cheng, Z., Truongcao, M.M., Benedict, C., Verma, S.K., Koch, W.J., Kishore, R., & Goukassian, D.A. (2018). Abstract 333: TNF Receptor Modulation of Progenitor Cells and Exosomes for Myocardial Repair. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.333.

  • Pfleger, J.M., Gross, P., Johnson, J., Gao, E., Houser, S.R., & Koch, W.J. (2018). G Protein-coupled Receptor Kinase 2 Impairs Fatty Acid Metabolism in the Failing Heart Through Novel Mechanisms. CIRCULATION RESEARCH, 123. 10.1161/res.123.suppl_1.109

  • Gan, L., Xie, D., Zhao, D., Gao, E., Koch, W.J., Wang, Y., & Ma, X. (2018). Abstract 220: Adipocyte-Derived Exosome-Containing miRNAs Exacerbated Cardiac Ischemia/Reperfusion Injury in Diabetic Mice. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.220.

  • Ponnalagu, D., Patel, N.J., Gao, E., Koch, W.J., Kohut, A.R., & Singh, H. (2018). Abstract 292: Mitochondrial CLIC4 and CLIC5B Mediate Cardio-protection From Ischemia/reperfusion Injury. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.292.

  • Lieu, M., Chuprun, K., Gao, E., & Koch, W.J. (2018). Abstract 318: MicroRNA Regulation of G Protein-Coupled Receptor Kinase 2 After Cardiac Injury. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.318.

  • Wang, Y., Gan, L., Xie, D., Zhao, D., Gao, E., Koch, W.J., & Ma, X. (2018). Abstract 557: Exosome Biogenesis/Uptake Mediates Cardioprotection by Globular Adiponectin but Not High Molecular Weight Adiponectin. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.557.

  • Grisanti, L.A., Thomas, T.P., Lucia, C.d., Carter, R.L., Gao, E., Koch, W.J., Benovic, J.L., & Tilley, D.G. (2018). Abstract 580: A β-arrestin-Biased β2-Adrenergic Receptor-Specific Pepducin Confers Cardioprotection. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.580.

  • Okyere, A.D., Lucia, C.d., Song, J., Carter, R.L., Benovic, J.L., Koch, W.J., Cheung, J.Y., & Tilley, D.G. (2018). Abstract 578: β-arrestin-Biased β2-Adrenergic Receptor Signaling Enhances Cardiomyocyte Contractility via ROCK-Dependent Signaling. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.578.

  • Tomar, D., Shanmughapriya, S., Roy, R., Zhang, X., Song, J., Schumacher, S.M., Madesh, M., Cheung, J.Y., Koch, W.J., & Rajan, S. (2018). The Role of Mitochondrial Calcium Uniporter Complex in Cardiac Contractility and Function. CIRCULATION RESEARCH, 123. 10.1161/res.123.suppl_1.366

  • Gresham, K.S. & Koch, W.J. (2018). Abstract 312: Cardiomyocyte-secreted Signaling Factors Modulate Adipocyte Differentiation And Function. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.312.

  • Eguchi, A. & Koch, W.J. (2018). Abstract 262: GRK5 is a Novel Regulator of Fibroblast Activation. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.262.

  • Yeh, S., Zambrano, C., Koch, W., & Purcell, N. (2018). Abstract 311: In vitro Regulation of G-protein Coupled Receptor Kinase 5 (GRK5) Induced Cardiac Hypertrophy by a Novel Interaction With the Phosphatase PHLPP2. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.311.

  • Garikipati, V.N., Verma, S.K., Cheng, Z., Liang, D., Truongcao, M.M., Cimini, M., Wang, C., Benedict, C., Ibetti, J., Grisanti, L., Schumacher, S.M., Gao, E., Rajan, S., Wilusz, J.E., Goukassian, D., Houser, S., Koch, W.J., & Kishore, R. (2018). Abstract 288: Circular RNA CircFNDC3b Modulates Cardiac Repair After Myocardial Infarction via FUS-1/VEGF-A Axis. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.288.

  • Grisanti, L., Schumacher, S., Tilley, D., & Koch, W. (2018). Designer Approaches for G Protein–Coupled Receptor Modulation for Cardiovascular Disease. JACC: Basic to Translational Science, 3(4), 550-562. doi: 10.1016/j.jacbts.2017.12.002.

  • Cheng, L., Al-Owais, M., Covarrubias, M., Koch, W., Manning, D., Peers, C., & Galdo, N.R. (2018). Coupling of smoothened to inhibitory G proteins reduces voltage-gated K+ currents in cardiomyocytes and prolongs cardiac action potential duration. Journal of Biological Chemistry, 293(28), 11022-11032. doi: 10.1074/jbc.RA118.001989.

  • Yeh, S., Zambrano, C., Koch, W., & Purcell, N. (2018). PH domain leucine-rich repeat protein phosphatase 2 (PHLPP2) regulates G-protein– coupled receptor kinase 5 (GRK5)-induced cardiac hypertrophy in vitro. Journal of Biological Chemistry, 293(21), 8056-8064. doi: 10.1074/jbc.M117.809913.

  • Hayashi, H., Hess, D., Zhang, R., Sugi, K., Gao, H., Tan, B., Bowles, D., Milano, C., Jain, M., Koch, W., & Stamler, J. (2018). S-Nitrosylation of β-Arrestins Biases Receptor Signaling and Confers Ligand Independence. Molecular Cell, 70(3), 473-487.e6. doi: 10.1016/j.molcel.2018.03.034.

  • Seo, S., Kim, N., Lee, J., Kim, S., Lee, S., Bae, J., Hwang, K., Kim, D., Koch, W., & Cho, M. (2018). β-arrestin2 affects cardiac progenitor cell survival through cell mobility and tube formation in severe hypoxia. Korean Circulation Journal, 48(4), 296-309. doi: 10.4070/kcj.2017.0119.

  • Lymperopoulos, A., McCrink, K.A., Maning, J., Brill, A., Desimine, V.L., Wertz, S.L., & Koch, W. (2018). CARVEDILOL EXERTS POSITIVE INOTROPY IN CARDIOMYOCYTES BY UNIQUELY STIMULATING BETA-ARRESTIN2-DEPENDENT SERCA2A ACTIVITY VIA THE BETA1-ADRENERGIC RECEPTOR. Journal of the American College of Cardiology, 71(11), a933. doi: 10.1016/s0735-1097(18)31474-8.

  • Ponnalagu, D., Patel, N.J., Chaudhury, A., Gao, E., Koch, W.J., Kohut, A.R., & Singh, H. (2018). CLIC4 and CLIC5, Mitochondrial Chloride Channel Proteins Mediate Cardioprotection Against Ischemia Reperfusion Injury. Biophysical Journal, 114(3), 657a. doi: 10.1016/j.bpj.2017.11.3551.

  • Cannavo, A. & Koch, W. (2018). GRK2 as negative modulator of NO bioavailability: Implications for cardiovascular disease. Cellular Signalling, 41, 33-40. doi: 10.1016/j.cellsig.2017.01.014.

  • Grisanti, L., Thomas, T., Carter, R., Lucia, C.d., Gao, E., Koch, W., Benovic, J., & Tilley, D. (2018). Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling. Theranostics, 8(17), 4664-4678. doi: 10.7150/thno.26619.

  • Lucia, C.D., Gambino, G., Petraglia, L., Elia, A., Komici, K., Femminella, G., D'Amico, M., Formisano, R., Borghetti, G., Liccardo, D., Nolano, M., Houser, S., Leosco, D., Ferrara, N., Koch, W., & Rengo, G. (2018). Long-term caloric restriction improves cardiac function, remodeling, adrenergic responsiveness, and sympathetic innervation in a model of postischemic heart failure. Circulation: Heart Failure, 11(3). doi: 10.1161/CIRCHEARTFAILURE.117.004153.

  • McCrink, K., Maning, J., Vu, A., Jafferjee, M., Marrero, C., Brill, A., Bathgate-Siryk, A., Dabul, S., Koch, W., & Lymperopoulos, A. (2017). Cardiac βarrestin2 Improves Contractility and Adverse Remodeling in Heart Failure, But Is Underexpressed in Humans. Journal of the American College of Cardiology, 70(23), 2948-2949. doi: 10.1016/j.jacc.2017.10.008.

  • Bouley, R., Waldschmidt, H., Cato, M., Cannavo, A., Song, J., Cheung, J., Yao, X., Koch, W., Larsen, S., & Tesmer, J. (2017). Structural determinants influencing the potency and selectivity of indazole-paroxetine hybrid G protein-coupled receptor kinase 2 inhibitors. Molecular Pharmacology, 92(6), 707-717. doi: 10.1124/mol.117.110130.

  • Yan, W., Guo, Y., Tao, L., Lau, W., Gan, L., Yan, Z., Guo, R., Gao, E., Wong, G., Koch, W., Wang, Y., & Ma, X. (2017). C1q/Tumor Necrosis Factor-Related Protein-9 Regulates the Fate of Implanted Mesenchymal Stem Cells and Mobilizes Their Protective Effects Against Ischemic Heart Injury via Multiple Novel Signaling Pathways. Circulation, 136(22), 2162-2177. doi: 10.1161/CIRCULATIONAHA.117.029557.

  • Wang, Y., Liang, B., Lau, W., Du, Y., Guo, R., Yan, Z., Gan, L., Yan, W., Zhao, J., Gao, E., Koch, W., & Ma, X. (2017). Restoring diabetes-induced autophagic flux arrest in ischemic/reperfused heart by ADIPOR (adiponectin receptor) activation involves both AMPK-dependent and AMPK-independent signaling. Autophagy, 13(11), 1855-1869. doi: 10.1080/15548627.2017.1358848.

  • Sato, P., Chuprun, J.K., Grisanti, L., Woodall, M., Traynham, C., Lucchese, A.M., Yuan, A., Ibetti, J., Tilley, D., Gao, E., & Koch, W. (2017). GRK2-S670A Mice reveal cardioprotection post ischemia-reperfusion. Journal of Molecular and Cellular Cardiology, 112, 152-153. doi: 10.1016/j.yjmcc.2017.07.067.

  • McCrink, K., Maning, J., Vu, A., Jafferjee, M., Marrero, C., Brill, A., Bathgate-Siryk, A., Dabul, S., Koch, W., & Lymperopoulos, A. (2017). β-Arrestin2 Improves Post-Myocardial Infarction Heart Failure via Sarco(endo)plasmic Reticulum Ca2+-ATPase-Dependent Positive Inotropy in Cardiomyocytes. Hypertension, 70(5), 972-981. doi: 10.1161/HYPERTENSIONAHA.117.09817.

  • Guo, S., Carter, R., Grisanti, L., Koch, W., & Tilley, D. (2017). Impact of paroxetine on proximal β-adrenergic receptor signaling. Cellular Signalling, 38, 127-133. doi: 10.1016/j.cellsig.2017.07.006.

  • Jean-Charles, P., Yu, S., Abraham, D., Kommaddi, R., Mao, L., Strachan, R., Zhang, Z., Bowles, D., Brian, L., Stiber, J., Jones, S., Koch, W., Rockman, H., & Shenoy, S. (2017). Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling. JCI Insight, 2(17). doi: 10.1172/JCI.INSIGHT.95998.

  • Verma, S., Garikipati, V., Krishnamurthy, P., Schumacher, S., Grisanti, L., Cimini, M., Cheng, Z., Khan, M., Yue, Y., Benedict, C., Truongcao, M., Rabinowitz, J., Goukassian, D., Tilley, D., Koch, W., & Kishore, R. (2017). Interleukin-10 inhibits bone marrow fibroblast progenitor cell-mediated cardiac fibrosis in pressure-overloaded myocardium. Circulation, 136(10), 940-953. doi: 10.1161/CIRCULATIONAHA.117.027889.

  • McCrink, K.A., Maning, J., Brill, A., Vu, A., Koch, W.J., & Lymperopoulos, A. (2017). Abstract P224: β-arrestin2 Stimulates SERCA2a SUMOylation and Activity in Cardiac Myocytes to Promote Contractility. Hypertension, 70(suppl_1). doi: 10.1161/hyp.70.suppl_1.p224.

  • Schumacher, S. & Koch, W. (2017). Noncanonical Roles of G Protein-coupled Receptor Kinases in Cardiovascular Signaling. Journal of Cardiovascular Pharmacology, 70(3), 129-141. doi: 10.1097/FJC.0000000000000483.

  • Cannavo, A., Liccardo, D., Komici, K., Corbi, G., Lucia, C.d., Femminella, G., Elia, A., Bencivenga, L., Ferrara, N., Koch, W., Paolocci, N., & Rengo, G. (2017). Sphingosine kinases and sphingosine 1-phosphate receptors: Signaling and actions in the cardiovascular system. Frontiers in Pharmacology, 8(AUG). doi: 10.3389/fphar.2017.00556.

  • Grisanti, L.A., Lucia, C.d., Gao, E., Koch, W.J., Benovic, J.L., & Tilley, D.G. (2017). Abstract 299: Cardioprotection from Ischemia/Reperfusion Injury by β-Arrestin-Biased β2-Adrenergic Receptor Activation. Circulation Research, 121(suppl_1). doi: 10.1161/res.121.suppl_1.299.

  • Wang, Y., Lau, W., Lopez, B., Christopher, T., Gao, E., Koch, W., & Ma, X.X. (2017). Abstract 362: Restoring Diabetes-induced Autophagic Flux Arrestment in Ischemic/Reperfused Heart by Adiponectin Receptor Activation Involves Both AMPK-Dependent and AMPK-Independent Signaling. Circulation Research, 121(suppl_1). doi: 10.1161/res.121.suppl_1.362.

  • Yan, W., Lau, W., Christopher, T., Lopez, B., Gao, E., Koch, W., Wang, Y., & Ma, X.X. (2017). Abstract 308: CTRP9 Regulates the Fate of Implanted Mesenchymal Stem Cells and Mobilizes Their Protective Effects Against Ischemic Heart Injury via Multiple Novel Signaling Pathways. Circulation Research, 121(suppl_1). doi: 10.1161/res.121.suppl_1.308.

  • Cannavo, A., Rengo, G., Liccardo, D., Pun, A., Gao, E., George, A., Gambino, G., Rapacciuolo, A., Leosco, D., Ibanez, B., Ferrara, N., Paolocci, N., & Koch, W. (2017). β 1 -Blockade Prevents Post-Ischemic Myocardial Decompensation Via β 3 AR-Dependent Protective Sphingosine-1 Phosphate Signaling. Journal of the American College of Cardiology, 70(2), 182-192. doi: 10.1016/j.jacc.2017.05.020.

  • Garikipati, V., Verma, S., Jolardarashi, D., Cheng, Z., Ibetti, J., Cimini, M., Tang, Y., Khan, M., Yue, Y., Benedict, C., Nickoloff, E., Truongcao, M., Gao, E., Krishnamurthy, P., Goukassian, D., Koch, W., & Kishore, R. (2017). Therapeutic inhibition of miR-375 attenuates post-myocardial infarction inflammatory response and left ventricular dysfunction via PDK-1-AKT signalling axis. Cardiovascular Research, 113(8), 938-949. doi: 10.1093/cvr/cvx052.

  • Schlegel, P., Reinkober, J., Meinhardt, E., Tscheschner, H., Gao, E., Schumacher, S., Yuan, A., Backs, J., Most, P., Wieland, T., Koch, W., Katus, H., & Raake, P. (2017). G protein-coupled receptor kinase 2 promotes cardiac hypertrophy. PLoS ONE, 12(7). doi: 10.1371/journal.pone.0182110.

  • Lucia, C.D., Komici, K., Borghetti, G., Femminella, G., Bencivenga, L., Cannavo, A., Corbi, G., Ferrara, N., Houser, S., Koch, W., & Rengo, G. (2017). MicroRNA in cardiovascular aging and age-related cardiovascular diseases. Frontiers of Medicine, 4. doi: 10.3389/fmed.2017.00074.

  • Waldschmidt, H., Homan, K., Cato, M., Cruz-Rodríguez, O., Cannavo, A., Wilson, M., Song, J., Cheung, J., Koch, W., Tesmer, J., & Larsen, S. (2017). Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. Journal of Medicinal Chemistry, 60(7), 3052-3069. doi: 10.1021/acs.jmedchem.7b00112.

  • Cannavo, A., Liccardo, D., Lymperopoulos, A., Santangelo, M., Femminella, G., Leosco, D., Cittadini, A., Ferrara, N., Paolocci, N., Koch, W., & Rengo, G. (2017). GRK2 Regulates α2-Adrenergic Receptor–Dependent Catecholamine Release in Human Adrenal Chromaffin Cells. Journal of the American College of Cardiology, 69(11), 1515-1517. doi: 10.1016/j.jacc.2017.01.016.

  • Cannavo, A. & Koch, W. (2017). Targeting β3-adrenergic receptors in the heart: Selective agonism and β-blockade. Journal of Cardiovascular Pharmacology, 69(2), 71-78. doi: 10.1097/FJC.0000000000000444.

  • Eisner, V., Cupo, R., Gao, E., Csordás, G., Slovinsky, W., Paillard, M., Cheng, L., Ibetti, J., Chen, S., Chuprun, J., Hoek, J., Koch, W., & Hajnóczky, G. (2017). Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity. Proceedings of the National Academy of Sciences of the United States of America, 114(5), E859-E868. doi: 10.1073/pnas.1617288114.