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John Elrod

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John Elrod

  • Lewis Katz School of Medicine

    • Center for Translational Medicine

      • Associate Professor

Biography

With a diverse training background ranging from genetics, molecular biology, and high-throughput screening to numerous animal models of disease the ultimate goal of our laboratory is to discover novel mechanisms of disease with a focus on clinical translation. Our lab is primarily focused on aspects of mitochondrial biology, metabolism, and cell death in the context of cardiac injury, heart failure, and neurodegeneration. We have made seminal contributions to our understanding of the molecular regulation of mitochondrial calcium exchange and its role in physiology and disease.

Google Scholar: John Elrod

Labs: John Elrod

Research Interests

  • Genetic Components of Mitochondrial Calcium Exchange
  • cellular physiology and heart disease
  • Genome-wide Functional Screening
  • novel modulators
  • necrotic cell death program

Courses Taught

Number

Name

Level

BMSC 8900

Organ Systems and Translational Medicine Student Seminar and Journal Club

Graduate

Selected Publications

Recent

  • Jadiya, P., Garbincius, J., & Elrod, J. (2021). Reappraisal of metabolic dysfunction in neurodegeneration: Focus on mitochondrial function and calcium signaling. Acta Neuropathologica Communications, 9(1). doi: 10.1186/s40478-021-01224-4.

  • Joseph, L., Reyes, M., Homan, E., Gowen, B., Avula, U., Goulbourne, C., Wan, E., Elrod, J., & Morrow, J. (2021). The mitochondrial calcium uniporter promotes arrhythmias caused by high-fat diet. Scientific Reports, 11(1). doi: 10.1038/s41598-021-97449-3.

  • Schena, G., Murray, E., Hildebrand, A., Headrick, A., Yang, Y., Koch, K., Kubo, H., Eaton, D., Johnson, J., Berretta, R., Mohsin, S., Kishore, R., McKinsey, T., Elrod, J., & Houser, S. (2021). Cortical bone stem cell-derived exosomes' therapeutic effect on myocardial ischemia-reperfusion and cardiac remodeling. American Journal of Physiology - Heart and Circulatory Physiology, 231(6), H1-H16. doi: 10.1152/ajpheart.00197.2021.

  • Garbincius, J.F. & Elrod, J.W. (2021). Mitochondrial calcium exchange in physiology and disease. Physiological Reviews. doi: 10.1152/physrev.00041.2020.

  • Murashige, D., Jang, C., Neinast, M., Levin, M., Jung, J.W., Lambert, J.P., Garbincius, J., Kim, B., Marti-Pamies, I., Flam, E., Hoshino, A., Yang, S., Roberts, E., Li, L., Assoian, R.K., Elrod, J.W., Rabinowitz, J., & Arany, Z. (2021). Abstract P388: Extra-cardiac BCAA Catabolism Lowers Blood Pressure And Protects From Heart Failure. Circulation Research, 129(Suppl_1). doi: 10.1161/res.129.suppl_1.p388.

  • Dietsche, F., Zhang, L., Elrod, J., & Methner, A. (2021). MICU1 opens the gates to cold-induced death. Cell Calcium, 98. doi: 10.1016/j.ceca.2021.102451.

  • Zamani, P., Proto, E., Wilson, N., Fazelinia, H., Ding, H., Spruce, L., Davila, A., Hanff, T., Mazurek, J., Prenner, S., Desjardins, B., Margulies, K., Kelly, D., Arany, Z., Doulias, P., Elrod, J., Allen, M., McCormack, S., Schur, G., D'Aquilla, K., Kumar, D., Thakuri, D., Prabhakaran, K., Langham, M., Poole, D., Seeholzer, S., Reddy, R., Ischiropoulos, H., & Chirinos, J. (2021). Multimodality assessment of heart failure with preserved ejection fraction skeletal muscle reveals differences in the machinery of energy fuel metabolism. ESC Heart Failure, 8(4), 2698-2712. doi: 10.1002/ehf2.13329.

  • Gibb, A., Murray, E., Eaton, D., Huynh, A., Tomar, D., Garbincius, J., Kolmetzky, D., Berretta, R., Wallner, M., Houser, S., & Elrod, J. (2021). Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model. JACC: Basic to Translational Science, 6(8), 650-672. doi: 10.1016/j.jacbts.2021.07.004.

  • Saxena, R., Saribas, S., Jadiya, P., Tomar, D., Kaminski, R., Elrod, J., & Safak, M. (2021). Human neurotropic polyomavirus, JC virus, agnoprotein targets mitochondrion and modulates its functions. Virology, 553, 135-153. doi: 10.1016/j.virol.2020.11.004.

  • Garbincius, J. & Elrod, J. (2021). Is the Failing Heart Starved of Mitochondrial Calcium? Circulation Research, 1205-1207. doi: 10.1161/CIRCRESAHA.121.319030.

  • Gross, P., Johnson, J., Romero, C., Eaton, D., Poulet, C., Sanchez-Alonso, J., Lucarelli, C., Ross, J., Gibb, A., Garbincius, J., Lambert, J., Varol, E., Yang, Y., Wallner, M., Feldsott, E., Kubo, H., Berretta, R., Yu, D., Rizzo, V., Elrod, J., Sabri, A., Gorelik, J., Chen, X., & Houser, S. (2021). Interaction of the Joining Region in Junctophilin-2 with the L-Type Ca2+Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca2+Dynamics. Circulation Research, 92-114. doi: 10.1161/CIRCRESAHA.119.315715.

  • Tomar, D. & Elrod, J. (2020). Metabolite regulation of the mitochondrial calcium uniporter channel. Cell Calcium, 92. doi: 10.1016/j.ceca.2020.102288.

  • Garbincius, J.F., Luongo, T.S., Lambert, J.P., Mangold, A.S., Murray, E.K., Hildebrand, A.N., Jadiya, P., & Elrod, J.W. (2020). Abstract 16592: Excessive MCU-Mediated Mitochondrial Calcium Uptake During Chronic Stress Impairs Cardiac Contractility. Circulation, 142(Suppl_3). doi: 10.1161/circ.142.suppl_3.16592.

  • Gibb, A.A., Murray, E.K., Eaton, D.M., Huynh, A.T., Tomar, D., Garbincius, J.F., Kolmetzky, D.W., Berretta, R.M., Wallner, M., Houser, S.R., & Elrod, J.W. (2020). Abstract 16434: Temporal Metabolomic and Transcriptomic Changes in a Large-Animal Model of Hfpef. Circulation, 142(Suppl_3). doi: 10.1161/circ.142.suppl_3.16434.

  • Gibb, A.A., Murray, E.K., Huynh, A.T., Lombardi, A.A., Lorkiewicz, P.K., Kolmetzky, D.W., Lazaropoulos, M.P., Arany, Z.P., Kelly, D.P., Margulies, K.B., Hill, B.G., & Elrod, J.W. (2020). Abstract 16406: Epigenetic Regulation of Myofibroblast Differentiation and Persistence is Mediated by Enhanced Glutaminolysis. Circulation, 142(Suppl_3). doi: 10.1161/circ.142.suppl_3.16406.

  • Lazaropoulos, M.P., Gibb, A.A., Huynh, A., Wellen, K., & Elrod, J.W. (2020). Abstract 15978: Acetyl-coa Catalysis by Atp-citrate Lyase is Essential for Myofibroblast Differentiation and Persistence. Circulation, 142(Suppl_3). doi: 10.1161/circ.142.suppl_3.15978.

  • Tomar, D., Thomas, M., Garbincius, J., Kolmetzky, D., Salik, O., jadiya, p., Joseph, S.K., Carpenter, A.C., Hajnoczky, G., & Elrod, J.W. (2020). Abstract 15070: Micu1 Regulates Mitochondrial Cristae Structure and Function Independent of the Mitochondrial Calcium Uniporter Channel. Circulation, 142(Suppl_3). doi: 10.1161/circ.142.suppl_3.15070.

  • Hernansanz-Agustín, P., Choya-Foces, C., Carregal-Romero, S., Ramos, E., Oliva, T., Villa-Piña, T., Moreno, L., Izquierdo-Álvarez, A., Cabrera-García, J., Cortés, A., Lechuga-Vieco, A., Jadiya, P., Navarro, E., Parada, E., Palomino-Antolín, A., Tello, D., Acín-Pérez, R., Rodríguez-Aguilera, J., Navas, P., Cogolludo, Ã., López-Montero, I., Martínez-del-Pozo, Ã., Egea, J., López, M., Elrod, J., Ruíz-Cabello, J., Bogdanova, A., Enríquez, J., & Martínez-Ruiz, A. (2020). Na+ controls hypoxic signalling by the mitochondrial respiratory chain. Nature, 586(7828), 287-291. doi: 10.1038/s41586-020-2551-y.

  • Xia, H., Li, Z., Sharp, T., Polhemus, D., Carnal, J., Moles, K., Tao, Y., Elrod, J., Pfeilschifter, J., Beck, K., & Lefer, D. (2020). Endothelial cell cystathionine γ-lyase expression level modulates exercise capacity, vascular function, and myocardial ischemia reperfusion injury. Journal of the American Heart Association, 9(19). doi: 10.1161/JAHA.120.017544.

  • Garbincius, J.F., Luongo, T.S., Lambert, J.P., Mangold, A.S., Murray, E.K., Hildebrand, A.N., Jadiya, P., & Elrod, J.W. (2020). Abstract 506: Enhanced Mitochondrial Calcium Uptake During Chronic β-adrenergic Stimulation Causes Maladaptive Remodeling and Impaired Left Ventricular Function Independent of Cyclophilin D-mediated Mitochondrial Permeability Transition. Circulation Research, 127(Suppl_1). doi: 10.1161/res.127.suppl_1.506.

  • Tomar, D., Thomas, M., Kolmetzky, D., Salik, O., Garbincius, J., Jadiya, P., Carpenter, A.C., & Elrod, J.W. (2020). Micu1 Regulates Mitochondrial Structural Integrity and Cristae Function Independent of Mcu Calcium Uptake. CIRCULATION RESEARCH, 127. 10.1161/res.127.suppl_1.270

  • Gibb, A., Lazaropoulos, M., & Elrod, J. (2020). Myofibroblasts and fibrosis: Mitochondrial and metabolic control of cellular differentiation. Circulation Research, 127(3), 427-447. doi: 10.1161/CIRCRESAHA.120.316958.

  • Garbincius, J., Luongo, T., & Elrod, J. (2020). The debate continues – What is the role of MCU and mitochondrial calcium uptake in the heart? Journal of Molecular and Cellular Cardiology, 143, 163-174. doi: 10.1016/j.yjmcc.2020.04.029.

  • Yellamilli, A., Ren, Y., McElmurry, R., Lambert, J., Gross, P., Mohsin, S., Houser, S., Elrod, J., Tolar, J., Garry, D., & Berlo, J.v. (2020). Abcg2-expressing side population cells contribute to cardiomyocyte renewal through fusion. FASEB Journal, 34(4), 5642-5657. doi: 10.1096/fj.201902105R.

  • Lambert, J., Murray, E., & Elrod, J. (2020). MCUB and mitochondrial calcium uptake–modeling, function, and therapeutic potential. Expert Opinion on Therapeutic Targets, 24(3), 163-169. doi: 10.1080/14728222.2020.1732926.

  • Ahmad, F., Tomar, D., C, S.A.A., Elmoselhi, A., Thomas, M., Elrod, J., Tilley, D., & Force, T. (2020). Nicotinamide riboside kinase-2 alleviates ischemia-induced heart failure through P38 signaling. Biochimica Et Biophysica Acta - Molecular Basis of Disease, 1866(3). doi: 10.1016/j.bbadis.2019.165609.

  • Lombardi, A., Gibb, A., Arif, E., Kolmetzky, D., Tomar, D., Luongo, T., Jadiya, P., Murray, E., Lorkiewicz, P., Hajnóczky, G., Murphy, E., Arany, Z., Kelly, D., Margulies, K., Hill, B., & Elrod, J. (2019). Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation. Nature Communications, 10(1). doi: 10.1038/s41467-019-12103-x.

  • Jadiya, P., Kolmetzky, D., Tomar, D., Meco, A.D., Lombardi, A., Lambert, J., Luongo, T., Ludtmann, M., Praticò, D., & Elrod, J. (2019). Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease. Nature Communications, 10(1). doi: 10.1038/s41467-019-11813-6.

  • Lambert, J., Luongo, T., Tomar, D., Jadiya, P., Gao, E., Zhang, X., Lucchese, A., Kolmetzky, D., Shah, N., & Elrod, J. (2019). MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload during Stress. Circulation, 140(21), 1720-1733. doi: 10.1161/CIRCULATIONAHA.118.037968.

  • Wang, Y., He, S., Liu, Y., Hooper, R., Yu, H., Tian, Y., Tien, B., Schultz, B.M., Elrod, J.W., Soboloff, J., & Zhang, Y. (2019). Artesunate Inhibits Graft-Versus-Host Disease in Mice Via a Mechanism of Inducing Mitochondrial Calcium Overloading in Activated T Cells. Blood, 134(Supplement_1), 4432-4432. doi: 10.1182/blood-2019-131115.

  • Bahmed, K., Lin, C., Simborio, H., Karim, L., Aksoy, M., Kelsen, S., Tomar, D., Madesh, M., Elrod, J., Messier, E., Mason, R., Unterwald, E., Eisenstein, T., Criner, G., & Kosmider, B. (2019). The role of DJ-1 in human primary alveolar type II cell injury induced by e-cigarette aerosol. American Journal of Physiology - Lung Cellular and Molecular Physiology, 317(4), L475-L485. doi: 10.1152/AJPLUNG.00567.2018.

  • Lambert, J.P., Luongo, T.S., Tomar, D., Jadiya, P., Gao, E., Zhang, X., Lucchese, A.M., Kolmetzky, D.W., Shah, N., & Elrod, J.W. (2019). Abstract 857: MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel During Cardiac Stress to Limit Mitochondrial Calcium Overload. Circulation Research, 125(Suppl_1). doi: 10.1161/res.125.suppl_1.857.

  • Garbincius, J.F., Luongo, T.S., Kolmetzky, D.W., Hildebrand, A.N., & Elrod, J.W. (2019). Abstract 851: NCLX Expression Attenuates Pathological Remodeling in Experimental Cardiac Hypertrophy and Non-ischemic Heart Failure. Circulation Research, 125(Suppl_1). doi: 10.1161/res.125.suppl_1.851.

  • Murray, E.K., Lombardi, A.A., Lambert, J.P., & Elrod, J.W. (2019). Abstract 737: N -ethylmaleimide sensitive factor (NSF) is Essential in Necrotic Cell Death. Circulation Research, 125(Suppl_1). doi: 10.1161/res.125.suppl_1.737.

  • Murashige, D.S., Jang, C., Neinast, M.D., Elrod, J.W., Kelly, D.P., Rabinowitz, J.D., Frankel, D.S., & Arany, Z.P. (2019). Abstract 562: Comprehensive Arteriovenous Metabolomics in the Human Heart. Circulation Research, 125(Suppl_1). doi: 10.1161/res.125.suppl_1.562.

  • Gibb, A.A., Lombardi, A.A., Murray, E.K., Tan, Y., Lorkiewicz, P.K., Huynh, A.T., Kolmetzky, D.W., Arany, Z., Kelly, D.P., Margulies, K.B., Hill, B.G., & Elrod, J.W. (2019). Abstract 517: Glutaminolysis is Required to Initiate Myofibroblast Differentiation and Persistence During Stress. Circulation Research, 125(Suppl_1). doi: 10.1161/res.125.suppl_1.517.

  • Tomar, D., Garbincius, J.F., Kolmetzky, D., Thomas, M., Jadiya, P., & Elrod, J.W. (2019). Abstract 101: Identification of Novel MICU1 Interactors Independent of the mtCU Complex. Circulation Research, 125(Suppl_1). doi: 10.1161/res.125.suppl_1.101.

  • Gibb, A. & Elrod, J. (2019). Not just correlative: A new pathway defines how an ALDH2 SNP contributes to atherosclerosis. Journal of Clinical Investigation, 129(1). doi: 10.1172/JCI125433.

  • Fuente, S.D.L., Lambert, J., Nichtova, Z., Sanz, C.F., Elrod, J., Sheu, S., & Csordás, G. (2018). Spatial Separation of Mitochondrial Calcium Uptake and Extrusion for Energy-Efficient Mitochondrial Calcium Signaling in the Heart. Cell Reports, 24(12), 3099-3107.e4. doi: 10.1016/j.celrep.2018.08.040.

  • Lambert, J.P., Luongo, T.S., Jadiya, P., Gao, E., Lucchesee, A.M., Zhang, X., Kolmetzky, D.W., Shah, N., & Elrod, J.W. (2018). Abstract 539: MCUB Regulates the Macromolecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Ischemic Cardiac Injury. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.539.

  • Guo, S., Lambert, J., Song, J., Carter, R., Lucchese, A.M., Gao, E., Cheung, J., Elrod, J., & Tilley, D. (2018). Abstract 423: Cardiomyocyte-Specific Epidermal Growth Factor Receptor Deletion Differentially Alters Cardiac Contractility and Remodeling During Physiologic versus Pathologic Development. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.423.

  • Garbincius, J.F., Luongo, T.S., Lambert, J.P., & Elrod, J.W. (2018). Abstract 277: Enhanced Mitochondrial Calcium Uptake Promotes Deleterious Remodeling and Impaired Left Ventricular Function During Chronic Adrenergic Stimulation. Circulation Research, 123(Suppl_1). doi: 10.1161/res.123.suppl_1.277.

  • Stein, C., Jadiya, P., Zhang, X., McLendon, J., Abouassaly, G., Witmer, N., Anderson, E., Elrod, J., & Boudreau, R. (2018). Mitoregulin: A lncRNA-Encoded Microprotein that Supports Mitochondrial Supercomplexes and Respiratory Efficiency. Cell Reports, 23(13), 3710-3720.e8. doi: 10.1016/j.celrep.2018.06.002.

  • Elrod, J. & Gustafsson, Ã. (2018). Editorial overview: Mitochondria – Master regulators of cellular function. Current Opinion in Physiology, 3, iv-vi. doi: 10.1016/j.cophys.2018.05.001.

  • Antony, A.N., Katona, M., Juskeviciute, E., Elrod, J.W., Hajnóczky, G., & Hoek, J.B. (2018). Fine‐tuning of hepatocyte calcium signaling and liver regeneration by the mitochondrial calcium uniporter. The FASEB Journal, 32(S1), 536.10-536.10. doi: 10.1096/fasebj.2018.32.1_supplement.536.10.

  • Galluzzi, L., Vitale, I., Aaronson, S., Abrams, J., Adam, D., Agostinis, P., Alnemri, E., Altucci, L., Amelio, I., Andrews, D., Annicchiarico-Petruzzelli, M., Antonov, A., Arama, E., Baehrecke, E., Barlev, N., Bazan, N., Bernassola, F., Bertrand, M., Bianchi, K., Blagosklonny, M., Blomgren, K., Borner, C., Boya, P., Brenner, C., Campanella, M., Candi, E., Carmona-Gutierrez, D., Cecconi, F., Chan, F., Chandel, N., Cheng, E., Chipuk, J., Cidlowski, J., Ciechanover, A., Cohen, G., Conrad, M., Cubillos-Ruiz, J., Czabotar, P., D'Angiolella, V., Dawson, T., Dawson, V., Laurenzi, V.D., Maria, R.D., Debatin, K., Deberardinis, R., Deshmukh, M., Daniele, N.D., Virgilio, F.D., Dixit, V., Dixon, S., Duckett, C., Dynlacht, B., El-Deiry, W., Elrod, J., Fimia, G., Fulda, S., García-Sáez, A., Garg, A., Garrido, C., Gavathiotis, E., Golstein, P., Gottlieb, E., Green, D., Greene, L., Gronemeyer, H., Gross, A., Hajnoczky, G., Hardwick, J., Harris, I., Hengartner, M., Hetz, C., Ichijo, H., Jäättelä, M., Joseph, B., Jost, P., Juin, P., Kaiser, W., Karin, M., Kaufmann, T., Kepp, O., Kimchi, A., Kitsis, R., Klionsky, D., Knight, R., Kumar, S., Lee, S., Lemasters, J., Levine, B., Linkermann, A., Lipton, S., Lockshin, R., López-Otín, C., Lowe, S., Luedde, T., Lugli, E., MacFarlane, M., Madeo, F., Malewicz, M., Malorni, W., & Manic, G. (2018). Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation, 25(3), 486-541. doi: 10.1038/s41418-017-0012-4.

  • Fuente, S.D.l., Fernadez-Sanz, C., Lambert, J.P., Elrod, J.W., Sheu, S., & Csordas, G. (2018). The Spatial Distribution of the Na+/Ca2+ Exchanger in Cardiac Mitochondria Enhances the Efficincy of the Mitochondrial Ca2+ Signal Generation. Biophysical Journal, 114(3), 659a. doi: 10.1016/j.bpj.2017.11.3561.

  • Natarajaseenivasan, K., Cotto, B., Shanmughapriya, S., Lombardi, A., Datta, P., Madesh, M., Elrod, J., Khalili, K., & Langford, D. (2018). Astrocytic metabolic switch is a novel etiology for Cocaine and HIV-1 Tat-mediated neurotoxicity article. Cell Death and Disease, 9(4). doi: 10.1038/s41419-018-0422-3.

  • Lombardi, A. & Elrod, J. (2017). Mediating ER-mitochondrial cross-talk. Science, 358(6363), 591-592. doi: 10.1126/science.aaq0141.

  • Fuente, S.D.L., Fernandez-Sanz, C., Lambert, J., Elrod, J., Sheu, S., & Csordas, G. (2017). The spatial distribution of the Na+/Ca2+ exchanger in cardiac mitochondria enhances the efficiency of mitochondrial Ca2+ signal generation. Journal of Molecular and Cellular Cardiology, 112, 169. doi: 10.1016/j.yjmcc.2017.07.114.

  • Lambert, J.P., Luongo, T.S., Jadiya, P., Gao, E., Zhang, X., Lucchesee, A.M., & Elrod, J.W. (2017). Abstract 432: MCUB Regulates Mitochondrial Calcium Uniporter Channel Gating and Modulates Bioenergetics and Cell Death. Circulation Research, 121(suppl_1). doi: 10.1161/res.121.suppl_1.432.

  • Lombardi, A.A., Arif, E., Luongo, T.S., & Elrod, J.W. (2017). Abstract 279: Mitochondrial Bioenergetic Signaling Drives Myofibroblast Transdifferentiation. Circulation Research, 121(suppl_1). doi: 10.1161/res.121.suppl_1.279.

  • Luongo, T., Lambert, J., Gross, P., Nwokedi, M., Lombardi, A., Shanmughapriya, S., Carpenter, A., Kolmetzky, D., Gao, E., Berlo, J.V., Tsai, E., Molkentin, J., Chen, X., Madesh, M., Houser, S., & Elrod, J. (2017). The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability. Nature, 545(7652), 93-97. doi: 10.1038/nature22082.

  • Jadiya, P., Lombardi, A.A., Lambert, J.P., Luongo, T.S., Chu, J., Praticò, D., & Elrod, J.W. (2017). Genetic Rescue of Mitochondrial Calcium Efflux in Alzheimer's Disease Preserves Mitochondrial Function and Protects against Neuronal Cell Death. Biophysical Journal, 112(3), 445a. doi: 10.1016/j.bpj.2016.11.2383.

  • Lombardi, A.A., Arif, E., Luongo, T.S., & Elrod, J.W. (2017). Genetic Ablation of Fibroblast Mitochondrial Calcium Uptake Increases Myofibroblast Transdifferentiation and Exacerbates Fibrosis in Myocardial Infarction. Biophysical Journal, 112(3), 96a. doi: 10.1016/j.bpj.2016.11.558.