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Vincenzo Carnevale

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Vincenzo Carnevale

  • College of Science and Technology

    • Chemistry

      • Research Professor

Research Interests

  • Evolutionary conservation of structural dynamics
  • Networks of coevolving residues

Courses Taught

Number

Name

Level

SCTC 1001

CST First Year Seminar

Undergraduate

BIOL 5411

Structural Bioinformatics I

Graduate

Selected Publications

Recent

  • McGee, F., Hauri, S., Novinger, Q., Vucetic, S., Levy, R., Carnevale, V., & Haldane, A. (2021). The generative capacity of probabilistic protein sequence models. Nature Communications, 12(1). doi: 10.1038/s41467-021-26529-9.

  • Salcuni, A.S., Battista, C., Pugliese, F., Columbu, C., Guarnieri, V., Carnevale, V., & Scillitani, A. Normocalcemic primary hyperparathyroidism: an update. MINERVA ENDOCRINOLOGY, 46(3), 262-271. 10.23736/S2724-6507.20.03215-0

  • Chiodini, I., Gaudio, A., Palermo, A., Napoli, N., Vescini, F., Falchetti, A., Merlotti, D., Eller-Vainicher, C., Carnevale, V., Scillitani, A., Pugliese, G., Rendina, D., Salcuni, A., Bertoldo, F., Gonnelli, S., Nuti, R., Toscano, V., Triggiani, V., Cenci, S., & Gennari, L. (2021). Management of bone fragility in type 2 diabetes: Perspective from an interdisciplinary expert panel. NUTRITION METABOLISM and CARDIOVASCULAR DISEASES, 31(8), 2210-2233. 10.1016/j.numecd.2021.04.014

  • Pugliese, F., Salcuni, A., Battista, C., Carnevale, V., Guglielmi, G., Columbu, C., Velluzzi, F., Giovanelli, L., Eller-Vainicher, C., Scillitani, A., & Chiodini, I. Prevalence of less severe hypercortisolism in fractured patients admitted in an outpatient clinic for metabolic bone diseases. ENDOCRINE, 73(1), 203-208. 10.1007/s12020-021-02616-1

  • Carnevale, V., Delemotte, L., & Howard, R. (2021). Molecular Dynamics Simulations of Ion Channels. Trends in Biochemical Sciences, 46(7), 621-622. doi: 10.1016/j.tibs.2021.04.005.

  • Scalia, P., Pandini, G., Carnevale, V., Giordano, A., & Williams, S. (2021). Correction: Identification of a novel EphB4 phosphodegron regulated by the autocrine IGFII/IRA axis in malignant mesothelioma (Oncogene, (2019), 38, 31, (5987-6001), 10.1038/s41388-019-0854-y). Oncogene, 40(8), 1551. doi: 10.1038/s41388-020-01609-0.

  • Sperandeo, M., Tinti, M.G., Frongillo, E., Cosmo, S.D., Dimitri, L.M.C., Grimaldi, M.A., Carnevale, V., Simeone, A., & Cipriani, C. Transthoracic Ultrasound-Guided Fine Needle Aspiration Biopsy in the Differential Diagnosis of Granulomatosis With Polyangiitis. JCR-JOURNAL of CLINICAL RHEUMATOLOGY, 26(5), E140-E141. 10.1097/RHU.0000000000001022

  • Suma, A., Stopar, A., Nicholson, A., Castronovo, M., & Carnevale, V. (2020). Global and local mechanical properties control endonuclease reactivity of a DNA origami nanostructure. Nucleic Acids Research, 48(9), 4672-4680. doi: 10.1093/nar/gkaa080.

  • Kasimova, M., Lynagh, T., Sheikh, Z., Granata, D., Borg, C., Carnevale, V., & Pless, S. (2020). Evolutionarily Conserved Interactions within the Pore Domain of Acid-Sensing Ion Channels. Biophysical Journal, 118(4), 861-872. doi: 10.1016/j.bpj.2019.09.001.

  • Chernov-Rogan, T., Gianti, E., Liu, C., Villemure, E., Cridland, A., Hu, X., Ballini, E., Lange, W., Deisemann, H., Li, T., Ward, S., Hackos, D., Magnuson, S., Safina, B., Klein, M., Volgraf, M., Carnevale, V., & Chen, J. (2020). Erratum: TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism (Proceedings of the National Academy of Sciences of the United States of America (2019) 116 (26008–26019) DOI: 10.1073/pnas.1913929116). Proceedings of the National Academy of Sciences of the United States of America, 117(4), 2226-2227. doi: 10.1073/pnas.1922373117.

  • Chernov-Rogan, T., Gianti, E., Liu, C., Villemure, E., Cridland, A., Hu, X., Ballini, E., Lange, W., Deisemann, H., Li, T., Ward, S., Hackos, D., Magnuson, S., Safina, B., Klein, M., Volgraf, M., Carnevale, V., & Chen, J. (2019). TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism. Proceedings of the National Academy of Sciences of the United States of America, 116(51), 26008-26019. doi: 10.1073/pnas.1913929116.

  • Piontek, S., Tuladhar, A., Marshall, T., & Borguet, E. (2019). Monovalent and Divalent Cations at the α-Al2O3(0001)/Water Interface: How Cation Identity Affects Interfacial Ordering and Vibrational Dynamics. Journal of Physical Chemistry C, 123(30), 18315-18324. doi: 10.1021/acs.jpcc.9b01618.

  • Scalia, P., Pandini, G., Carnevale, V., Giordano, A., & Williams, S. (2019). Identification of a novel EphB4 phosphodegron regulated by the autocrine IGFII/IRA axis in malignant mesothelioma. Oncogene, 38(31), 5987-6001. doi: 10.1038/s41388-019-0854-y.

  • Palmieri, S., Bedeschi, M., Cairoli, E., Morelli, V., Lunati, M., Scillitani, A., Carnevale, V., Lalatta, F., Barbieri, A., Orsi, E., Spada, A., Chiodini, I., & Eller-Vainicher, C. Bone involvement and mineral metabolism in Williams' syndrome. JOURNAL of ENDOCRINOLOGICAL INVESTIGATION, 42(3), 337-344. 10.1007/s40618-018-0924-y

  • Filardi, T., Carnevale, V., Massoud, R., Russo, C., Nieddu, L., Tavaglione, F., Turinese, I., Lenzi, A., Romagnoli, E., & Morano, S. High serum osteopontin levels are associated with prevalent fractures and worse lipid profile in post-menopausal women with type 2 diabetes. JOURNAL of ENDOCRINOLOGICAL INVESTIGATION, 42(3), 295-301. 10.1007/s40618-018-0914-0

  • Suma, A., Stopar, A., Adedeji, A., Nicholson, A.W., Castronovo, M., & Carnevale, V. (2019). DNA Origami-Protein Interactions and the Role of Steric Hindrance. BIOPHYSICAL JOURNAL, 116(3), 319A-319A. 10.1016/j.bpj.2018.11.1729

  • Hughes, T., Pumroy, R., Yazici, A., Kasimova, M., Fluck, E.C., Huynh, K., Samanta, A., Molugu, S.K., Zhou, H., Carnevale, V., Rohacs, T., & Moiseenkova-Bell, V. (2019). Structural Insights on TRPV5 Gating by Endogenous Modulators. BIOPHYSICAL JOURNAL, 116(3), 534A-534A. 10.1016/j.bpj.2018.11.2873

  • Yazici, A.T., Gianti, E., Kasimova, M.A., Carnevale, V., & Rohacs, T. (2019). Phosphatidylinositol Inhibits TRPV1 via its Vanilloid Binding Site. BIOPHYSICAL JOURNAL, 116(3), 536A-536A. Retrieved from http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000460779802695&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=abcd71df5a6dac31fd219478b0a9c638.

  • Gianti, E., Klein, M.L., Rohacs, T., & Carnevale, V. (2019). Activation of TRPV1 by Lipids: Can Lipid Tails Bridge the Gap between the Vanilloid Binding Site and the Peripheral Cavities? BIOPHYSICAL JOURNAL, 116(3), 536A-536A. 10.1016/j.bpj.2018.11.2885

  • Roose, B., Zemerov, S., Wang, Y., Kasimova, M., Carnevale, V., & Dmochowski, I. (2019). A Structural Basis for 129Xe Hyper-CEST Signal in TEM-1 β-Lactamase. ChemPhysChem, 20(2), 260-267. doi: 10.1002/cphc.201800624.

  • Wang, R., Dellostritto, M., Remsing, R., Carnevale, V., Klein, M., & Borguet, E. (2019). Sodium Halide Adsorption and Water Structure at the α-Alumina(0001)/Water Interface. Journal of Physical Chemistry C. doi: 10.1021/acs.jpcc.9b03054.

  • Sariyer, I., Gordon, J., Burdo, T., Wollebo, H., Gianti, E., Donadoni, M., Bellizzi, A., Cicalese, S., Loomis, R., Robinson, J., Carnevale, V., Steiner, J., Ozdener, M., Miller, A., Amini, S., Klein, M., & Khalili, K. (2019). Suppression of Zika Virus Infection in the Brain by the Antiretroviral Drug Rilpivirine. Molecular Therapy. doi: 10.1016/j.ymthe.2019.10.006.

  • Kasimova, M., Yazici, A., Yudin, Y., Granata, D., Klein, M., Rohacs, T., & Carnevale, V. (2018). A hypothetical molecular mechanism for TRPV1 activation that invokes rotation of an S6 asparagine. Journal of General Physiology, 150(11), 1554-1566. doi: 10.1085/jgp.201812124.

  • Carnevale, V., Castriotta, V., Piscitelli, P.A., Nieddu, L., Mattera, M., Guglielmi, G., & Scillitani, A. Assessment of Skeletal Muscle Mass in Older People: Comparison Between 2 Anthropometry-Based Methods and Dual-Energy X-ray Absorptiometry. JOURNAL of the AMERICAN MEDICAL DIRECTORS ASSOCIATION, 19(9), 793-796. 10.1016/j.jamda.2018.05.016

  • Sperandeo, M., Tinti, M.G., & Carnevale, V. Thoracic Ultrasound Artifacts: Still a Matter of Discussion. AMERICAN JOURNAL of KIDNEY DISEASES, 71(6), 910-910. 10.1053/j.ajkd.2018.01.050

  • Molinarolo, S., Lee, S., Leisle, L., Lueck, J., Granata, D., Carnevale, V., & Ahern, C. (2018). Cross-kingdom auxiliary subunit modulation of a voltage-gated sodium channel. Journal of Biological Chemistry, 293(14), 4981-4992. doi: 10.1074/jbc.RA117.000852.

  • Carnevalea, V. (2018). Protonation underlies tonic vs. use-dependent block. Proceedings of the National Academy of Sciences of the United States of America, 115(14), 3512-3514. doi: 10.1073/pnas.1802178115.

  • Howard, R., Carnevale, V., Delemotte, L., Hellmich, U., & Rothberg, B. (2018). Permeating disciplines: Overcoming barriers between molecular simulations and classical structure-function approaches in biological ion transport. Biochimica Et Biophysica Acta - Biomembranes, 1860(4), 927-942. doi: 10.1016/j.bbamem.2017.12.013.

  • Kasimova, M., Yazici, A., Yudin, Y., Rohacs, T., & Carnevale, V. (2018). Role of Hydrophobic Solvation in TRPV1 Temperature Sensitivity. BIOPHYSICAL JOURNAL, 114(3), 481A-481A. Retrieved from http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000430563200164&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=abcd71df5a6dac31fd219478b0a9c638.

  • Gianti, E., Klein, M., Rohacs, T., & Carnevale, V. (2018). Molecular Insights into TRPV1 Polymodal Activation: Is Allosteric Coupling between the Toxin and the Vanilloid Binding Sites Mediated by Annular Lipids? BIOPHYSICAL JOURNAL, 114(3), 396A-396A. 10.1016/j.bpj.2017.11.2190

  • Molinarolo, S., Granata, D., Carnevale, V., & Ahern, C. (2018). Mining protein evolution for insights into mechanisms of voltage-dependent sodium channel auxiliary subunits. doi: 10.1007/164_2017_75.

  • Gianti, E. & Carnevale, V. (2018). Computational Approaches to Studying Voltage-Gated Ion Channel Modulation by General Anesthetics. doi: 10.1016/bs.mie.2018.01.002.

  • Granata, D., Ponzoni, L., Micheletti, C., & Carnevale, V. (2017). Patterns of coevolving amino acids unveil structural and dynamical domains. Proceedings of the National Academy of Sciences of the United States of America, 114(50), E10612-E10621. doi: 10.1073/pnas.1712021114.

  • Steinberg, X., Kasimova, M., Cabezas-Bratesco, D., Galpin, J., Ladron-de-Guevara, E., Villa, F., Carnevale, V., Islas, L., Ahern, C., & Brauchi, S. (2017). Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid. ELife, 6. doi: 10.7554/eLife.28626.

  • Woll, K., Skinner, K., Gianti, E., Bhanu, N., Garcia, B., Carnevale, V., Eckenhoff, R., & Gaudet, R. (2017). Sites Contributing to TRPA1 Activation by the Anesthetic Propofol Identified by Photoaffinity Labeling. Biophysical Journal, 113(10), 2168-2172. doi: 10.1016/j.bpj.2017.08.040.

  • Wang, R., Millan, K., Remsing, R., Piontek, S., Tuladhar, A., Magidson, L., Carnevale, V., Klein, M., & Borguet, E. (2017). Molecular dynamics simulations of alkali halide adsorption to water-alumina interfaces. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 254. Retrieved from http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000429556702565&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=abcd71df5a6dac31fd219478b0a9c638.

  • Razavi, A., Delemotte, L., Berlin, J., Carnevale, V., & Voelz, V. (2017). Molecular simulations and free-energy calculations suggest conformation-dependent anion binding to a cytoplasmic site as a mechanism for Na+/K+-ATPase ion selectivity. Journal of Biological Chemistry, 292(30), 12412-12423. doi: 10.1074/jbc.M117.779090.

  • Keulen, S.V., Gianti, E., Carnevale, V., Klein, M., Rothlisberger, U., & Delemotte, L. (2017). Does Proton Conduction in the Voltage-Gated H+ Channel hHv1 Involve Grotthuss-Like Hopping via Acidic Residues? Journal of Physical Chemistry B, 121(15), 3340-3351. doi: 10.1021/acs.jpcb.6b08339.

  • Gianti, E., Delemotte, L., Klein, M., & Carnevale, V. (2017). Exploiting water density fluctuations in ion channel drug design. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 253. Retrieved from http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000430568507653&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=abcd71df5a6dac31fd219478b0a9c638.

  • Carnevale, V. & Klein, M. (2017). Small molecule modulation of voltage gated sodium channels. Current Opinion in Structural Biology, 43, 156-162. doi: 10.1016/j.sbi.2017.02.002.

  • Delemotte, L., Keulen, S.v., Roethlisberger, U., Gianti, E., Carnevale, V., & Klein, M.L. (2017). Does Proton Conduction in the Voltage-Gated Proton Channel hH(V)1 Involve Grotthus Hopping via Acidic Residues? BIOPHYSICAL JOURNAL, 112(3), 163A-164A. 10.1016/j.bpj.2016.11.899

  • Kasimova, M., Lynagh, T., Granata, D., Pless, S., & Carnevale, V. (2017). Evolutionary Analysis Discriminates between Alternative ASIC Structures. BIOPHYSICAL JOURNAL, 112(3), 417A-417A. 10.1016/j.bpj.2016.11.2234

  • Yang, E., Granata, D., Eckenhoff, R., Carnevale, V., & Covarrubias, M. (2017). Propofol is a Potent Gating Modifier of Voltage-Gated Sodium Channels. BIOPHYSICAL JOURNAL, 112(3), 105A-106A. 10.1016/j.bpj.2016.11.601

  • Kasimova, M., Yazici, A., Granata, D., Rohacs, T., & Carnevale, V. (2017). Dynamic Solvation of Protein Cavities Underlies TRPV1 Gating. BIOPHYSICAL JOURNAL, 112(3), 466A-466A. 10.1016/j.bpj.2016.11.2500

  • Kasimova, M., Yazici, A., Cao, C., Velisetty, P., Carnevale, V., & Rohacs, T. (2017). The Mechanism of Regulation of TRPV6 Channels by PI(4,5)P-2. BIOPHYSICAL JOURNAL, 112(3), 114A-115A. 10.1016/j.bpj.2016.11.646

  • Colenso, C.K., Cabezas, D., Granata, D., Carnevale, V., Opazo, J.C., Ahern, C.A., & Brauchi, S.E. (2017). Intra-Molecular Connectivity in Sensory Receptors of the TRP Family. BIOPHYSICAL JOURNAL, 112(3), 8A-8A. 10.1016/j.bpj.2016.11.071